Role of circulating vascular endothelial growth factor and hepatocyte growth factor in patients with coronary artery disease
Role of circulating vascular endothelial growth factor and hepatocyte growth factor in patients with coronary artery disease
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DOI：
10.1007/pl00007263
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发表时间：
2000-01-01
影响因子：
1.5
通讯作者：
Fukuda, N
中科院分区：
文献类型：
--
作者：
Soeki, T;Tamura, Y;Fukuda, N
血管内皮生长因子（VEGF）和肝细胞生长因子（HGF）被认为在体内刺激内皮细胞增殖并诱导血管生成。然而，冠心病患者VEGF和HGF释放的确切机制仍不清楚。本文对20例急性心肌梗死（AMI）和20例稳定型心绞痛（AP）患者进行了负荷心肌血流灌注显像，并测定了血清VEGF和HGF浓度。陈旧性心肌梗死（OMI）患者16例，无可逆性心肌负荷显像异常。对照组包括20例冠状动脉造影正常的非典型胸痛患者。采用酶联免疫吸附法测定血清VEGF和HGF浓度。AMI患者心肌梗死早期血清VEGF、HGF浓度均高于AP、OMI及对照组。AP患者VEGF浓度高于OMI患者，而AP和OMI患者HGF浓度无差异。入院时有梗死前心绞痛的AMI患者的VEGF浓度高于无梗死前心绞痛的患者，而两组患者的HGF浓度无差异。这些结果表明，血清VEGF浓度可能比血清HGF浓度更能反映心肌缺血。
Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are thought to stimulate endothelial cell proliferation and induce angiogenesis in vivo. However, the precise mechanism responsible for VEGF and HGF release in patients with coronary artery disease is still unknown. We studied serum concentrations of VEGF and HGF in 20 patients with acute myocardial infarction (AMI), 20 patients with stable angina pectoris (AP) who had reversible perfusion defects on stress myocardial scintigraphy. and 16 patients with old myocardial infarction (OMI) who had no reversible defects on stress myocardial scintigraphy. The control group consisted of 20 patients with atypical chest pain who had angiographically normal coronary arteries. Serum VEGF and HGF concentrations were measured by enzyme-linked immunosorbent assay. Both the serum VEGF and HGF concentrations in the early stage of myocardial infarction in the patients with AMI were higher than those in the patients with AP and with OMI, and control patients. The VEGF concentration in the patients with AP was higher than in the patients with OMI, whereas the HGF concentration did not differ in the patients with AP and OMI. The VEGF concentration in AMI patients who had had preinfarction angina on admission was higher than that of patients who had had no preinfarction angina, whereas the HGF concentration did not differ between the two groups of patients. These results suggest that the serum VEGF concentration may reflect myocardial ischemia to a greater degree than the serum HGF concentration.