Relationship of homocysteine to markers of platelet and endothelial activation in 'high risk' hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial
Relationship of homocysteine to markers of platelet and endothelial activation in 'high risk' hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial
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DOI：
10.1016/j.ijcard.2003.06.002
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发表时间：
2004-04-01
影响因子：
3.5
通讯作者：
Lip, GYH
中科院分区：
文献类型：
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作者：
Spencer, CGC;Martin, SC;Lip, GYH
目的：探讨高血压高危人群血浆同型半胱氨酸（HCY）与血液流变学、血管内皮及血小板标志物的关系。设计：横断面研究。受试者和方法：共有165名连续高血压患者（136名男性;平均年龄63岁（SD）8))沿着38名血压正常的健康对照者，对入选盎格鲁-斯堪的纳维亚心脏结局试验（阿斯科特）的100名心血管疾病高危人群进行研究。我们测量了血浆同型半胱氨酸[高压液相色谱法（HPLC）]、可溶性P-选择素（血小板功能的标志物）、血管性血友病因子（vWF）（内皮损伤/功能障碍的指标[均通过ELISA法]）和纤维蛋白原（CLAUSS）的水平。计算Fragrance心血管和脑血管风险评分。结果如下：高血压患者的血压（BP）[165/90（16/10）vs. 138/82（12/8）mm Hg，p < 0.0001]、sP-sel [54（44-67）vs. 45（35-57）ng/ml，p = 0.002]、vWF [133（34）vs. 110（28）IU/dl，p < 0.0001]、和纤维蛋白原[2.98（2.52 - 3.47）vs. 2.43（2.20-2.83）g/l，p=
Objective: To examine the relationship between plasma homocysteine (HCY) and theological, endothelial and platelet markers in 'high risk' hypertensive patients. Design: Cross-sectional study. Subjects and Methods: A total of 165 consecutive hypertensive patients (136 male; mean age 63 years (S.D. 8)) at high risk of cardiovascular disease who screened for inclusion in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) were studied along with 38 population normotensive healthy controls. We measured levels of plasma homocysteine [high pressure liquid chromatography (HPLC)], soluble P-selectin, a marker of platelet function, von Willebrand factor (vWF), an index of endothelial damage/dysfunction [both by ELISA] and fibrinogen (CLAUSS). The Framingham cardiovascular and cerebrovascular risk scores were calculated. Results: Hypertensives had significantly higher blood pressure (BP) [165/90(16/10) vs. 138/82(12/8) mm Hg, p < 0.0001], sP-sel [54(44-67) vs. 45(35-57) ng/ml, p = 0.002], vWF [133(34) vs. 110(28) IU/dl, p < 0.0001], and fibrinogen [2.98(2.523.47) vs. 2.43(2.20-2.83)g/l, p=