Classification of Obesity with Respect to Morbidity
Classification of Obesity with Respect to Morbidity
复制标题
肥胖与发病率的分类
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
S. Tarui
中科院分区：
文献类型：
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作者：
Y. Matsuzawa;S. Fujioka;K. Tokunaga;S. Tarui
肥胖的定义是脂肪组织在体内过度堆积。由于它的病因和发病机制是非常不同的，按特定目的对疾病类型进行分类对于适当的临床治疗是必不可少的。虽然表一中给出的病因学分类对于诊断导致肥胖的原发病是有用的，但将单纯性肥胖分为亚组并确定每种疾病类型的病理特征将更有意义，因为在日常医疗中更常见的是没有特定可识别原因的简单服从。从这一观点出发，按照脂肪细胞的形态类型或脂肪组织聚集的部位进行了分类，如表1第二部分和第三部分所示，并对每种疾病类型的特点进行了综述。本文对此进行了详细的解释，并描述了一种与传统方法相比较的结合内脏脂肪概念的分类方法。至于内脏脂肪的积聚部位，可以用一种新开发的方法进行分析。脂肪组织细胞学特征分类这是根据活检的脂肪组织的细胞密度，即脂肪细胞的大小和数量(1)来分类。使用以下分类是因为肥胖伴随的代谢障碍与脂肪细胞的大小有关，也因为脂肪细胞的增殖能力与肥胖的发生之间的关系。增塑型。脂肪细胞大小正常，但数量增加。据说，脂肪细胞从胚胎期(怀孕的最后三个月)到出生后一年，再到青春期，都会活跃增殖。因此，这种类型常见于青年发病的肥胖者。由于脂肪细胞不大，新陈代谢紊乱很少发生。减肥的治疗效果不是很好。
Obesity is defined as an excess accumulation of adipose tissue in the body. Since its etiology and pathogenesis are quite heterogenous, classification of disease types by specific purposes is essential for proper clinical management. Although classification by the etiology given in Table I is useful for diagnosing the primary disease inducing obesity, it would be more meaningful to classify simple obesity into subgroups and determine pathological features of each disease type, since simple obesities without specific identifiable cause are much more often encountered in daily medical care. From this viewpoint, classification by morphological types of fat cells or by sites of adipose tissue accumulation has been carried out as shown in Parts II and III of Table I, and features of each disease type have been reviewed. This paper explains the above in detail, and describes a method of classification that incorporates the concept of visceral fats in comparison with conventional methods. As for the accumulation sites, visceral fat can be analyzed by a newly developed method. Classification by Cytological Features of Adipose Tissue This is to classify obesities by cellularity of the adipose tissue biopsied, i.e., by the size and number of fat cells (1). The following classifications are employed because metabolic disorders accompanying obesity are related to the size of fat cells and because of the relationship between the proliferative capacity of fat cells and the onset of obesity. Hyperplastic Type. Fat cells are normal in size, but are increased in number. Fat cells are said to actively proliferate from the embryonal period (the last trimester of pregnancy) to 1 year after birth, and again during puberty. This type is, therefore, often seen among obese people with onset in youth. Since fat cells are not large, metabolic disorders rarely occur. The treatment for weight reduction is not so effective.