Towards Organs on Demand: Breakthroughs and Challenges in Models of Organogenesis.
Towards Organs on Demand: Breakthroughs and Challenges in Models of Organogenesis.
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DOI：
10.1007/s40139-016-0111-9
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发表时间：
2016-09
影响因子：
--
通讯作者：
Lagasse E
中科院分区：
文献类型：
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作者：
Francipane MG;Lagasse E
近年来，通过组织工程方法，体外功能性三维（3D）组织生成已经显著地进步，与常规培养系统相比，实现了复杂的天然器官的更好的再现。本文将讨论传统的3D细胞培养技术以及新开发的技术平台。这些最新的技术为创造人体部位提供了新的可能性，并提供了对药物和化学挑战的组织反应的更准确预测。鉴于人类诱导多能干细胞（iPSC）领域的快速发展，这些平台在按需开发患者特异性可移植组织和器官方面也有很大的希望。
In recent years, functional three-dimensional (3D) tissue generation in vitro has been significantly advanced by tissue-engineering methods, achieving better reproduction of complex native organs compared to conventional culture systems. This review will discuss traditional 3D cell culture techniques as well as newly developed technology platforms. These recent techniques provide new possibilities in the creation of human body parts and provide more accurate predictions of tissue response to drug and chemical challenges. Given the rapid advancement in the human induced pluripotent stem cell (iPSC) field, these platforms also hold great promise in the development of patient-specific, transplantable tissues and organs on demand.