Effects of static magnetic fields on bone microstructure and mechanical properties in mice
Effects of static magnetic fields on bone microstructure and mechanical properties in mice
复制标题
静磁场对小鼠骨微结构和力学性能的影响
DOI：
10.1080/15368378.2018.1458626
复制
发表时间：
2018-01-01
影响因子：
1.7
通讯作者：
Shang, Peng
中科院分区：
文献类型：
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作者：
Zhang, Jian;Meng, Xiaofeng;Shang, Peng
所有生物都起源、进化和生活在地磁场（GMF，20-70 μ T）下。随着科学技术的飞速发展，自然和人为来源的各种静磁场（SMF）暴露对人体健康的潜在危害已成为一个公共环境话题。许多与健康效应相关的动物研究表明，SMF可以促进骨形成和促进骨愈合。此外，大多数研究集中在棒型磁体产生的局部SMF。SMF如何影响小鼠的骨代谢尚难得出结论。本研究采用低磁场（HyMF，500 nT）和中等磁场（MMF，0.2T），系统研究了磁场持续作用对骨组织显微结构和力学性能的影响。我们的结果清楚地表明，4周的MMF暴露没有影响骨生物力学性能或骨微结构，而HyMF显着抑制小鼠的生长和骨弹性。此外，矿质元素可能介导SMF的生物学效应。
All the living organisms originate, evolve and live under geomagnetic field (GMF, 20-70 mu T). With rapid development in science and technology, exposure to various static magnetic fields (SMFs) from natural and man-made sources remains a public environmental topic in consideration of its probable health risk for humans. Many animal studies related to health effect have demonstrated that SMF could improve bone formation and enhance bone healing. Moreover, most of the studies focused on local SMF generated by rod-type magnet. It was difficult to come to a conclusion that how SMF affected bone metabolism in mice. The present study employed hypomagnetic field (HyMF, 500nT), and moderate SMF (MMF, 0.2T) to systematically investigate the effects of SMF with continuous exposure on microstructure and mechanical properties of bone. Our results clearly indicated that 4-week MMF exposure did not affect bone biomechanical properties or bone microarchitecture, while HyMF significantly inhibited the growth of mice and elasticity of bone. Furthermore, mineral elements might mediate the biological effect of SMF.