Tamm-Horsfall proteinuria. Its relationship to prolonged nephrogram in infants and children and to renal failure following intravenous urography in adults with multiple myeloma.
Tamm-Horsfall proteinuria. Its relationship to prolonged nephrogram in infants and children and to renal failure following intravenous urography in adults with multiple myeloma.
复制标题
塔姆-霍斯福尔蛋白尿。
作者：
W. Berdon;R. Schwartz;J. Becker;D. Baker
在一组婴儿和儿童进行排泄性尿路造影时，可观察到持续数小时至数天的管状肾造影。这些患者都有一定程度的少尿，但在整个研究期间血压正常，肾盏口径正常，表明肾盏前造影剂积聚。大量的Tamm-Horsfall（T.H.）随后在几名患者出现利尿后发现尿粘蛋白（16）（表I）。这种粘蛋白是重要的，因为它已被证明在少尿或脱水的情况下形成粘性凝胶，导致肾小管堵塞。它不仅在各种类型肾病患者的管型中发现，而且甚至在死于肾衰竭的多发性骨髓瘤患者中形成管型的主要部分（5-8）。根据对T.H.的了解，对儿童患者的临床特征和X线片进行了回顾。蛋白质（4-8，13）。用curre对该蛋白进行初步体外测试.
A prolonged tubular nephrogram lasting hours to days has been seen in performing excretory urography in a group of infants and children. The patients shared in common some degree of oliguria but all were normotensive throughout the period of study and had calyces of normal caliber, indicating a precalyceal accumulation of contrast material. Large amounts of Tamm-Horsfall (T.H.) urinary mucoprotein (16) were subsequently found in several of the patients once diuresis occurred (Table I). This mucoprotein is of importance since it has been shown to form a viscid gel with resultant tubular blockage in conditions of oliguria or dehydration. It has been found not only in casts of patients with varying types of renal disease, but it even forms the main part of casts in multiple myeloma patients dying in renal failure (5–8). The clinical features and radiographs of the pediatric patients are reviewed in the light of known knowledge of T.H. protein (4–8, 13). Preliminary in vitro testing of this protein with curre...