Cutting Edge: Limited Specialization of Dendritic Cell Subsets for MHC Class II-Associated Presentation of Viral Particles
Cutting Edge: Limited Specialization of Dendritic Cell Subsets for MHC Class II-Associated Presentation of Viral Particles
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DOI：
10.4049/jimmunol.0901540
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发表时间：
2010-01-01
影响因子：
4.4
通讯作者：
Bachmann, Martin F.
中科院分区：
文献类型：
--
作者：
Keller, Susanne A.;Bauer, Monika;Bachmann, Martin F.
树突状细胞（Dendritic cells，DC）是最重要的APC。最近报道DC亚群对Ag的呈递存在二分法;在CD8（+）DC中，外源性Ag到达MHC I类途径，但不到达MHC II类途径，而CD8（-）DC仅处理MHC II类途径的Ag。在这项研究中，我们使用病毒样颗粒（VLP），以显示，CD8（+）和CD8（-）的DC有效地捕获和处理VLP与MHC II类在体内。相反，CD8（+）DC，而不是CD8（-）DC，交叉呈递VIP衍生肽。在VLP特异性Ab存在下，这种模式以Fc γ R依赖性方式改变，因为在这些条件下，两种DC亚群均未能有效交叉存在。因此，将病毒颗粒呈递给CD4（+）T细胞不限于不同的DC亚群，而将病毒颗粒呈递给CD8（+）T细胞仅限于CD8（+）DC。免疫学杂志，2010，184：26 - 29。
Dendritic cells (DCs) are the most important APC. It was recently reported that there is a dichotomy for Ag presentation by DC subsets; exogenous Ags reach the MHC class I pathway, but not the MHC class II pathway, in CD8(+) DCs, whereas CD8(-) DCs only process Ags for the MHC class II pathway. In this study, we used virus-like particles (VLPs) to show that CD8(+) and CD8(-) DCs efficiently capture and process VLPs for presentation in association with MHC class II in vivo. In contrast, CD8(+) DCs, but not CD8(-) DCs, cross presented VIP-derived peptides. This pattern was changed in an Fc gamma R-dependent fashion in the presence of VLP-specific Abs, because under those conditions both DC subsets failed to efficiently cross present. Thus, the presentation of viral particles to CD4(+) T cells is not restricted to distinct DC subsets, whereas the presentation of viral particles to CD8(+) T cells is limited to CD8(+) DCs. The Journal of Immunology, 2010, 184: 26-29.