Regional variation in vertebral bone density and trabecular architecture are influenced by osteoarthritic change and osteoporosis
Regional variation in vertebral bone density and trabecular architecture are influenced by osteoarthritic change and osteoporosis
复制标题
DOI：
10.1097/00007632-199710150-00014
复制
发表时间：
1997-10-15
期刊：
影响因子：
3
通讯作者：
Heggeness, MH
中科院分区：
文献类型：
--
作者：
Antonacci, MD;Hanson, DS;Heggeness, MH
研究设计：分析与年龄相关的骨关节炎疾病和骨丢失对人体脊柱皮质和松质骨密度的影响。通过一种新的计算机定量放射学方法对变化进行量化。使用这种方法，测定了特定区域的骨矿物质的相对损失和椎体内骨骼的特定重新分布，作为年龄相关性骨丢失和骨关节病变化的函数。通过一种新的计算机定量放射学方法来量化与年龄相关的无骨性和骨关节炎疾病对人类脊柱皮质和骨小梁密度的影响。背景数据综述，据作者所知，骨关节炎和与年龄相关的改变导致椎体内特定区域的骨矿物质的相对丢失从未被定量研究过。身体解剖时取自23名正常人类受试者的74块椎骨。用双能X线吸收法测量椎体，然后切片进行计算机定量摄影分析。关注矢状面和副矢状面的整体骨密度、局部松质骨密度和皮质骨密度(前皮质、上终板和下终板)。共对140个切片进行了分析。定量放射学显示了先前未描述的、明确的椎体内皮质和骨小梁结构和骨密度的模式，这些模式在椎骨中是一致的，但受到骨关节炎改变和骨丢失的强烈影响。结论：双能X线吸收法未发现或记录到这些改变。了解骨丢失的模式和了解骨关节炎的变化如何影响正常的骨丢失有助于深入了解衰老过程和骨关节炎疾病的病理生理学。了解椎骨内密度和显微解剖的变化可能会改进脊柱内固定和植入物的设计技术，并有助于阐明骨折等临床问题的发病机制。
Study Design, The effects of age-related osteoarthritic disease and bone loss on cortical and trabecular bone density in the human spine were analyzed. Changes were quantified by a new method of computed quantitative radiography. Using this method, the relative losses of bone mineral from specific areas and the specific redistribution of bone within vertebrae as a function of age-related bone loss and osteoarthritic change were determined.Objectives. To quantify the effects of age-related boneless and osteoarthritic disease on cortical and trabecular density in the human spine by the use of a new method of computed quantitative radiography.Summary of Background Data, To the authors' knowledge, osteoarthritic and age-related changes resulting in the relative loss of bone mineral from specific areas within vertebrae have never been quantitatively studied.Methods. Seventy-four vertebrae were obtained from 23 normal, human subjects at autopsy. Vertebral bodies were measured by dual-energy x-ray absorption, and then sectioned for analysis by computerized quantitative radiography. Attention was focused on overall bone density, regional cancellous bone density, and cortical bone density (anterior cortex, superior, and inferior endplates) for both mid-sagittal and para-sagittal sections. One hundred forty sections were so analyzed.Results. Quantitative radiography demonstrated previously undescribed, well defined patterns of cortical and trabecular architecture and bone density within vertebral bodies that were uniform among vertebrae, but strongly influenced by osteoarthritic change and bone loss. These changes were neither detected nor documented by dual-energy x-ray absorption.Conclusions. Understanding the patterns of bone loss and knowing how osteoarthritic change affects normal bone loss yields insight into the pathophysiology of the aging process and osteoarthritic disorders. Knowledge of the variations in density and microanatomy within vertebrae may improve techniques of internal fixation and design of spinal, implants, and help to clarify the pathogenesis of clinical problem such as fractures.