Metal dependent protein phosphatase PPM family in cardiac health and diseases.
Metal dependent protein phosphatase PPM family in cardiac health and diseases.
复制标题
心脏健康和疾病中的金属依赖性蛋白磷酸酶PPM家族
DOI：
10.1016/j.cellsig.2021.110061
复制
发表时间：
2021-09
影响因子：
4.8
通讯作者：
Wang, Yibin
中科院分区：
文献类型：
--
作者：
Gao, Chen;Cao, Nancy;Wang, Yibin
蛋白质磷酸化和去磷酸化在细胞功能的几乎每一个方面（包括心血管调节和疾病）中对信号转导至关重要。虽然蛋白激酶通常被认为是细胞信号传导中具有高度特异性和严格调控的分子驱动器，但由蛋白磷酸酶介导的去磷酸化也越来越受到重视，作为细胞信号传导的稳健性，特异性和稳态所必需的信号转导网络的重要组成部分。金属依赖性蛋白磷酸酶（PPM，也称为蛋白磷酸酶2C型，PP2C）属于高度保守的蛋白磷酸酶家族，具有独特的生物化学和分子生物学特征。越来越多的证据也表明PPM亚型在信号传导和细胞过程中的重要和特异性功能，包括增殖、衰老、凋亡和代谢。在生理水平上，PPM的异常表达和活性与人类主要疾病有关，包括癌症、神经系统和心血管疾病。最后，一些PPM成员的抑制剂已被开发为人类疾病的潜在治疗策略。在这篇综述中，我们将重点介绍PPM家族主要成员的生物化学和分子特征的背景信息，重点是它们在心脏病理生理学中的表现或潜在作用。还将强调目前的挑战和今后调查的可能方向。
Protein phosphorylation and dephosphorylation is central to signal transduction in nearly every aspect of cellular function, including cardiovascular regulation and diseases. While protein kinases are often regarded as the molecular drivers in cellular signaling with high specificity and tight regulation, dephosphorylation mediated by protein phosphatases is also gaining increasing appreciation as an important part of the signal transduction network essential for the robustness, specificity and homeostasis of cell signaling. Metal dependent protein phosphatases (PPM, also known as protein phosphatases type 2C, PP2C) belong to a highly conserved family of protein phosphatases with unique biochemical and molecular features. Accumulating evidence also indicates important and specific functions of individual PPM isoform in signaling and cellular processes, including proliferation, senescence, apoptosis and metabolism. At the physiological level, abnormal PPM expression and activity have been implicated in major human diseases, including cancer, neurological and cardiovascular disorders. Finally, inhibitors for some of the PPM members have been developed as a potential therapeutic strategy for human diseases. In this review, we will focus on the background information about the biochemical and molecular features of major PPM family members, with emphasis on their demonstrated or potential roles in cardiac pathophysiology. The current challenge and potential directions for future investigations will also be highlighted.
登录
查看更多内容
影响因子：
7.3
作者：
Chen, Mark J.;Dixon, Jack E.;Manning, Gerard
通讯作者：
Manning, Gerard
DOI：
10.1016/j.jacbts.2016.12.002
发表时间：
2017-03
期刊：
JACC. Basic to translational science
影响因子：
--
作者：
Akaike T;Du N;Lu G;Minamisawa S;Wang Y;Ruan H
通讯作者：
Ruan H
影响因子：
4.8
作者：
Hanada, M;Ninomiya-Tsuji, J;Tamura, S
通讯作者：
Tamura, S
影响因子：
3.3
作者：
Baril, Caroline;Sahmi, Malha;Therrien, Marc
通讯作者：
Therrien, Marc
影响因子：
6
作者：
Dvashi, Zeev;Shalom, Hadas Sar;Lavi, Sara
通讯作者：
Lavi, Sara