Voxel based morphometry reveals specific gray matter changes in primary dystonia
Voxel based morphometry reveals specific gray matter changes in primary dystonia
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DOI：
10.1002/mds.21619
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发表时间：
2007-08-15
影响因子：
8.6
通讯作者：
Poewe, Werner
中科院分区：
文献类型：
--
作者：
Egger, Karl;Mueller, Joerg;Poewe, Werner
本研究利用基于体素的形态测量法（VBM）评估了不同类型原发性肌张力障碍的脑组织改变模式。9例原发性全身性肌张力障碍（GD）， 11例原发性宫颈肌张力障碍（CD）， 11例原发性局灶性手肌张力障碍（FHD），以及31例年龄和性别匹配的对照组。与健康对照相比，原发性肌张力障碍患者（n = 31）双侧苍白球内、伏隔核、前额皮质以及单侧左侧下顶叶灰质体积增加。这是首次在不同类型的原发性肌张力障碍患者中使用VBM的研究，显示出灰质变化的共同模式。(c) 2007年运动障碍协会。
The present study assessed patterns of brain tissue alterations in different types of primary dystonia using voxel-based morphometry (VBM). Nine patients with primary generalized dystonia (GD), 11 patients with primary cervical dystonia (CD), and 11 patients with primary focal hand dystonia (FHD) as well as 31 age and gender-matched controls were included. When compared with healthy controls, patients with primary dystonia (n = 31) showed gray matter volume increase bilaterally in the globus pallidus internus, nucleus accumbens, prefrontal cortex, as well as unilaterally in the left inferior parietal lobe. This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes. (c) 2007 Movement Disorder Society.