Targeting angiogenesis in pancreatic cancer: rationale and pitfalls.
Targeting angiogenesis in pancreatic cancer: rationale and pitfalls.
复制标题
胰腺癌的靶向血管生成：基本原理和陷阱。
DOI：
10.1007/s00423-008-0280-z
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Korc,Murray
中科院分区：
文献类型：
--
作者：
Whipple,Chery;Korc,Murray
简介胰腺导管腺癌 (PDAC) 是一种高度侵袭性癌症，占胃肠道恶性肿瘤死亡人数的 20% 以上。 PDAC 通常在晚期才被诊断出来，这在一定程度上有助于解释其对化疗和放疗的高抵抗力。此外，PDAC 中的癌细胞具有很高的转移倾向，并且异常表达血管生成和侵袭的几个关键调节因子。化疗对平均生存期的影响不大，而且常常会引起副作用。应研究单独靶向血管生成或与其他方式联合靶向血管生成，以确定其是否可以提高生存率。材料和方法这篇综述总结了在血管生成中发挥关键作用的 PDAC 的改变，并概述了可能有助于靶向这种恶性肿瘤的血管生成的当前策略和治疗策略。
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer responsible for over 20% of deaths due to gastrointestinal malignancies. PDAC is usually diagnosed at an advanced stage which, in part, helps to explain its high resistance to chemotherapy and radiotherapy. In addition, the cancer cells in PDAC have a high propensity to metastasize and to aberrantly express several key regulators of angiogenesis and invasion. Chemotherapy has only provided a modest impact on mean survival and often induces side effects. Targeting angiogenesis alone or in combination with other modalities should be investigated to determine if it may provide for increased survival.Materials and methodsThis review summarizes the alterations in PDAC that play a critical role in angiogenesis and provides an overview of current and therapeutic strategies that may be useful for targeting angiogenesis in this malignancy.