Cellular functions of the DUBs
Cellular functions of the DUBs
复制标题
DOI：
10.1242/jcs.090985
复制
发表时间：
2012-01-15
影响因子：
4
通讯作者：
Urbe, Sylvie
中科院分区：
文献类型：
--
作者：
Clague, Michael J.;Coulson, Judy M.;Urbe, Sylvie
泛素化是一种可逆的翻译后修饰，已成为大多数复杂细胞过程的关键调节因子。它可能在范围上与磷酸化竞争，在复杂性上超过磷酸化。泛素化过程的动态性对于调控蛋白质的稳定性、维持泛素的稳态和控制泛素依赖的信号转导通路是非常重要的。人类基因组编码类似于80种活性去泛素化酶（DUB，也称为去泛素化酶），其对各种泛素链拓扑结构表现出不同的特异性谱。由于其逆转泛素化的能力，这些酶控制着广泛的关键细胞过程。在这篇评论中，我们讨论了DUBs的细胞功能，例如它们在管理膜运输和蛋白质质量控制中的作用。我们强调两个关键的信号通路Wnt和转化生长因子β（TGF-β）的途径，其中动态泛素化已成为一个关键的调节。我们还讨论了DUBs在细胞核中的作用，在那里它们控制转录活性和DNA修复途径。如需进一步阅读，请参阅相关文章：海勒D的《DNA修复中的遍在蛋白和SUMO概览》。Ulrich（J. Cell Sci. 125，249-254）。Annamaria Mocciaro和Michael Rape的“泛素依赖性细胞周期控制中的新兴调控机制”（J. Cell Sci. 125，255-263）。“Cellular functions of the DUBs”by Michael J. Clague et al.（J. Cell Sci. 125，277-286）。“E3泛素连接酶的HECT和环指家族一瞥”，Meredith B。Metzger等人（J. Cell Sci. 125，531-537）。Yelena Kravtsova-Ivantsiv和Aaron Ciechanover的“蛋白酶体降解的非经典泛素信号”（J. Cell Sci. 125，539-548）。安娜C的“没有人能独自吹出一首交响乐，不同的泛素连接如何合作协调NF-κ B B活性”。Schmukle和Henning Walczak（J. Cell Sci. 125，549-559）。
Ubiquitylation is a reversible post-translational modification that has emerged as a key regulator of most complex cellular processes. It may rival phosphorylation in scope and exceed it in complexity. The dynamic nature of ubiquitylation events is important for governing protein stability, maintaining ubiquitin homeostasis and controlling ubiquitin-dependent signalling pathways. The human genome encodes similar to 80 active deubiquitylating enzymes (DUBs, also referred to as deubiquitinases), which exhibit distinct specificity profiles towards the various ubiquitin chain topologies. As a result of their ability to reverse ubiquitylation, these enzymes control a broad range of key cellular processes. In this Commentary we discuss the cellular functions of DUBs, such as their role in governing membrane traffic and protein quality control. We highlight two key signalling pathways the Wnt and transforming growth factor beta (TGF-beta) pathways, for which dynamic ubiquitylation has emerged as a key regulator. We also discuss the roles of DUBs in the nucleus, where they govern transcriptional activity and DNA repair pathways.This article is part of a Minifocus on Ubiquitin. For further reading, please see related articles: 'Ubiquitin and SUMO in DNA repair at a glance' by Helle D. Ulrich (J. Cell Sci. 125, 249-254). 'Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control' by Annamaria Mocciaro and Michael Rape (J. Cell Sci. 125, 255-263). 'Cellular functions of the DUBs' by Michael J. Clague et al. (J. Cell Sci. 125, 277-286). 'HECT and RING finger families of E3 ubiquitin ligases at a glance' by Meredith B. Metzger et al. (J. Cell Sci. 125, 531-537). 'Non-canonical ubiquitin-based signals for proteasomal degradation' by Yelena Kravtsova-Ivantsiv and Aaron Ciechanover (J. Cell Sci. 125, 539-548). 'No one can whistle a symphony alone how different ubiquitin linkages cooperate to orchestrate NF-kappa B activity' by Anna C. Schmukle and Henning Walczak (J. Cell Sci. 125, 549-559).