Risk Markers for Limited Coronary Artery Calcium in Persons With Significant Aortic Valve Calcium (From the Multi-ethnic Study of Atherosclerosis).
Risk Markers for Limited Coronary Artery Calcium in Persons With Significant Aortic Valve Calcium (From the Multi-ethnic Study of Atherosclerosis).
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DOI：
10.1016/j.amjcard.2021.06.035
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发表时间：
2021-10-01
期刊：
影响因子：
--
通讯作者：
Whelton SP
中科院分区：
文献类型：
--
作者：
Razavi AC;Cardoso R;Dzaye O;Budoff M;Thanassoulis G;Post WS;Shah S;Berman DS;Nasir K;Blaha MJ;Whelton SP
主动脉瓣钙化（AVC）和冠状动脉钙化（CAC）的早期阶段包括共同的ASCVD风险因素，但AVC和CAC的负担之间存在相当大的异质性。我们试图确定与显着AVC的人之间的有限CAC相关的标志物。来自动脉粥样硬化多种族研究的325例受试者在访视1时无临床ASCVD且AVC ≥ 100 Agatston单位（Au）。采用改良Poisson回归计算有限CAC（0 - 99 Au）的多变量校正患病率。参与者的平均年龄为72.1岁，平均AVC评分为209，34%为女性。共有133名（41%）参与者的CAC <100，其中46/133的CAC = 0。年轻（PR = 1.40，95% CI：1.22 - 1.62，每10年）、女性（PR = 1.68，95% CI：1.28 - 2.20）和10年ASCVD低风险（PR = 2.30，95% CI：1.85 - 2.85）与有限CAC最密切相关。正常脂蛋白（a）和正常炎症指标与有限CAC均无显著相关性。血磷水平降低（PR = 1.15，95% CI：1.01 - 1.31;每降低0.5 mg/dL）和钙磷乘积降低（PR = 1.16，95% CI：1.02 - 1.34;每降低SD）与局限性CAC患病率增加约15%相关。总之，超过40%的人与显着的AVC有CAC。除了传统的危险因素外，低血磷和低钙磷乘积与局限性CAC的高患病率相关。
The early stages of aortic valve calcification (AVC) and coronary artery calcification (CAC) include shared ASCVD risk factors, yet there is considerable heterogeneity between the burden of AVC and CAC. We sought to identify the markers associated with limited CAC among persons with significant AVC. There were 325 participants from the Multi-Ethnic Study of Atherosclerosis without clinical ASCVD and with AVC ≥100 Agatston units (AU) at Visit 1. Multivariable-adjusted prevalence ratios for limited CAC (0-99 AU) were calculated using modified Poisson regression. Participants had a mean age of 72.1 years, median AVC score of 209, and 34% were women. A total of 133 (41%) participants had CAC <100, of whom 46/133 had CAC=0. Younger age (PR=1.40, 95% CI: 1.22-1.62, per 10-years), female sex (PR=1.68, 95% CI: 1.28-2.20), and low 10-year ASCVD risk (PR=2.30, 95% CI: 1.85-2.85) were most strongly associated with limited CAC. Neither a normal lipoprotein(a) nor normal measures of inflammation were significantly associated with limited CAC. Lower serum phosphate (PR=1.15, 95% CI: 1.01-1.31; per 0.5 mg/dL lower) and calcium-phosphate product (PR=1.16, 95% CI: 1.02-1.34; per SD lower) were associated with an approximately 15% higher prevalence of limited CAC. In conclusion, more than 40% of persons with significant AVC had CAC. Beyond traditional risk factors, lower serum phosphate and lower calcium-phosphate product were associated with a higher prevalence of limited CAC.
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影响因子：
24
作者：
Elmariah, Sammy;Delaney, Joseph A. C.;O'Brien, Kevin D.;Budoff, Matthew J.;Vogel-Claussen, Jens;Fuster, Valentin;Kronmal, Richard A.;Halperin, Jonathan L.
通讯作者：
Halperin, Jonathan L.
影响因子：
24
作者：
Grundy, Scott M.;Stone, Neil J.;Wijeysundera, Duminda N.
通讯作者：
Wijeysundera, Duminda N.
影响因子：
5.3
作者：
Bundy JD;Chen J;Yang W;Budoff M;Go AS;Grunwald JE;Kallem RR;Post WS;Reilly MP;Ricardo AC;Rosas SE;Zhang X;He J;CRIC Study Investigators
通讯作者：
CRIC Study Investigators
影响因子：
5
作者：
Bild, DE;Bluemke, DA;Tracy, RP
通讯作者：
Tracy, RP
DOI：
10.1016/j.echo.2007.11.011
发表时间：
2008-02-01
影响因子：
6.5
作者：
Stein, James H.;Korcarz, Claudia E.;Post, Wendy S.
通讯作者：
Post, Wendy S.