Reduced prevalence of hepatitis B surface antigen positivity among pregnant women born after the national implementation of immunoprophylaxis for babies born to hepatitis B virus-carrier mothers in Japan
Reduced prevalence of hepatitis B surface antigen positivity among pregnant women born after the national implementation of immunoprophylaxis for babies born to hepatitis B virus-carrier mothers in Japan
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日本对乙型肝炎病毒携带者母亲所生婴儿实施免疫预防后出生的孕妇乙型肝炎表面抗原阳性率降低
DOI：
10.1111/hepr.12943
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发表时间：
2017
影响因子：
4.2
通讯作者：
Tanaka J
中科院分区：
文献类型：
--
作者：
Sugiyama A;Ohisa M;Nagashima S;Yamamoto C;Channarena C;Fujii T;Akita T;Katayama K;Kudo Y;Tanaka J
目的我们旨在估计日本广岛出生年份分层孕妇中的B表面抗原（HBsAg）阳性率，并比较在日本实施针对B肝炎病毒（HBV）携带者母亲所生婴儿的国家免疫预防接种计划之前和之后出生的妇女的患病率。2010年4月1日至2011年3月31日期间在广岛县的诊所符合条件。从每个机构收集的列表包括调查项目，如年龄（孕妇的出生年份）和HBsAg和丙型肝炎病毒（HCV）抗体（抗HCV）检测结果，这些结果是匿名发布的，并且未从医疗记录中合并。结果在58家医院/诊所中的41家，15 233名和15 035名孕妇进行了HBsAg和抗-HCV检测，分别占2010财政年度25 546名新生儿的59.6%和58.9%。总体HBsAg阳性率为0.51%（95%置信区间[CI]，0.40-0.63%），在1986年以后出生的孕妇中观察到极低的患病率（0.10%; 95% CI，0.00-0.25%）。然而，本研究中的患病率略高于2001年至2006年日本红十字会血液中心首次献血者的全国值（0.31%）和中国地区特定值（0.46%）。抗-HCV阳性率无显著差异observed.ConclusionOnly两个孕妇出生后的预防计划实施HBsAg阳性。据估计，围产期HBV传播在下一代几乎完全被抑制。
AimWe aimed to estimate hepatitis B surface antigen (HBsAg) positivity among birth year‐stratified pregnant women in Hiroshima, Japan, and compare prevalence rates between women born before and after implementation of a national immunoprophylactic vaccination program for babies born to hepatitis B virus (HBV) carrier mothers in Japan.MethodsPregnant women who gave birth at all delivery hospitals/clinics in Hiroshima prefecture between 1 April 2010 and 31 March 2011 were eligible. Lists collected from each institution included survey items such as age (pregnant woman's birth year) and HBsAg and hepatitis C virus (HCV) antibody (anti‐HCV) test results, which were posted anonymously and non‐consolidated from medical records. We calculated the HBsAg and anti‐HCV prevalence in our cohort according to the mothers' birth year.ResultsIn 41 of 58 hospitals/clinics, 15 233 and 15 035 pregnant women underwent HBsAg and anti‐HCV testing, corresponding to 59.6% and 58.9% of 25 546 births in the 2010 fiscal year, respectively. The overall HBsAg positive rate was 0.51% (95% confidence interval [CI], 0.40–0.63%), and an extremely low prevalence (0.10%; 95% CI, 0.00–0.25%) was observed among pregnant women born after 1986. However, the prevalence in this study was slightly higher than the nationwide value (0.31%) and the Chugoku region‐specific value (0.46%) among first‐time blood donors at Japanese Red Cross blood centers between 2001 and 2006. No significant difference in anti‐HCV positivity was observed.ConclusionOnly two pregnant women born after the preventive program implementation were HBsAg‐positive. Perinatal HBV transmission is estimated to be almost completely inhibited in the next generation.