Paraganglioma of the urinary bladder
Paraganglioma of the urinary bladder
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DOI：
10.17511/jopm.2020.i04.11
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发表时间：
2020-04
期刊：
影响因子：
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通讯作者：
S. Fatima;Omaia Mahdy;S. W. Siddiqui
中科院分区：
文献类型：
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作者：
S. Fatima;Omaia Mahdy;S. W. Siddiqui
副神经节瘤是肾上腺外嗜铬细胞瘤。它们是从外胚层神经系统的嗜铬细胞发展而来的分泌儿茶酚胺的肿瘤。它们是罕见的肿瘤，占所有膀胱肿瘤的不到0.06%，占所有肾上腺外嗜铬细胞瘤的6%。它们来自膀胱壁层内交感神经系统的嗜铬组织。它们可以出现在膀胱的任何部位，好发于逼尿肌，最常见的部位是膀胱顶和三角区。它们可能是无功能的，也可能是有功能的。最常见的症状是高血压和血尿。功能性肿瘤通常表现为儿茶酚胺分泌过多的症状。患者通常患有高血压危象，可能伴有头痛、心悸、潮热和出汗。排尿后低血压和晕厥是另一种常见的表现。它们具有共同的遗传基础，并与许多遗传条件有关。它们通常是良性的，但没有可靠的形态学标准来区分良性和恶性形式。我们报告一位22岁女性，因血尿经病理证实为膀胱副神经节瘤。
Paragangliomas are extra-adrenal pheochromocytomas. They are catecholamine-secreting neoplasms developing from the chromaffin cells derived from the ectodermic neural system. They are rare neoplasms that account for less than 0.06% of all urinary bladder tumors and 6% of all extra-adrenal pheochromocytomas. They arise from chromaffin tissue of the sympathetic nervous system within the layers of the bladder wall. They can be present in any part of the bladder with a predilection for the detrusor muscle with the most common sites being the dome and trigone.They may be nonfunctional or functional. The most common symptoms are hypertension and hematuria. Functional tumors usually present with symptoms of excessive catecholamine secretion. The patient typically suffers from hypertensive crises that may be accompanied by headache, palpitations, hot flushes, and sweating. Postmicturition hypotension and syncope are another common presentations. They share a genetic basis and can be related to a number of hereditary conditions.They are usually benign but there are no reliable morphologic criteria by which to separate the benign from the malignant forms. Here we present a 22 years old female with hematuria which on histopathology proved to be paraganglioma of the urinary bladder.