The invisible arm of immunity in common cancer chemoprevention agents.
The invisible arm of immunity in common cancer chemoprevention agents.
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DOI：
10.1158/1940-6207.capr-13-0036
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Disis ML
中科院分区：
文献类型：
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作者：
Marzbani E;Inatsuka C;Lu H;Disis ML
免疫预防是指通过使用疫苗、抗体和免疫调节剂预防病原体相关和自发性癌症的策略。免疫调节剂通过增强免疫系统监测恶性肿瘤的内源性能力来发挥作用，即所谓的“免疫监视”。越来越多的证据表明，许多最有前途的癌症化学预防剂，包括阿司匹林，考克斯-2抑制剂，芳香酶抑制剂和二膦酸盐介导其作用，部分是通过增强免疫监视和逆转癌前病变所采用的免疫逃避机制。在下面的综述中，我们介绍了人类免疫监视系统的关键组成部分树突状细胞，T细胞和免疫抑制细胞，并讨论了新出现的数据表明，常见的化学预防剂可以调节这些免疫细胞的功能。
Immunoprevention refers to a strategy of preventing pathogen-associated and spontaneous cancers through the use of vaccines, antibodies, and immune modulators. Immune modulators function by enhancing the endogenous ability of the immune system to monitor for malignancy, so-called “immunosurveillance.” There is growing evidence that many of the most promising cancer chemoprevention agents including aspirin, COX-2 inhibitors, aromatase inhibitors, and bisphosphonates mediate their effects, in part, by enhancing immunosurveillance and reversing the immune evasive mechanisms that premalignant lesions employ. In the following review, we introduce critical components of the human immune surveillance system—dendritic cells, T cells, and immune suppressive cells—and discuss the emerging data suggesting that common chemoprevention agents may modulate the function of these immunologic cells.