Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.
Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.
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通过全血单克隆测定诊断 Bernard-Soulier 综合征和 Glanzmann 血小板无力症。
DOI：
10.1172/jci110780
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Corcoran
中科院分区：
文献类型：
--
作者：
R. Montgomery;T. Kunicki;C. Taves;D. Pidard;M. Corcoran
两种遗传性血小板疾病，Bernard-Soulier综合征和Glanzmann's血栓减少症，以血小板膜糖蛋白选择性缺陷为特征。制备了血小板膜糖蛋白Ib和糖蛋白IIb/IIIa复合物的小鼠单克隆抗体。研究人员开发了一种检测这些糖蛋白缺乏症的快速全血检测方法，并将其用于研究6名Glanzmann血栓缺失症患者和3名Bernard-Soulier综合征患者的全血样本。I型和II型格兰兹曼血栓减少症患者很容易被检测到。这允许在血液取样后2小时内用200微升全血诊断这些疾病。
Two hereditary platelet disorders, Bernard-Soulier syndrome and Glanzmann's thrombasthenia, are characterized by selective deficiencies of platelet membrane glycoproteins. Murine monoclonal antibodies were developed against platelet membrane glycoprotein Ib and against the glycoprotein IIb/IIIa complex. A rapid whole blood assay for the deficiency of these glycoproteins was developed and used to study whole blood samples from six patients with Glanzmann's thrombasthenia and three patients with Bernard-Soulier syndrome. Patients with type I and type II Glanzmann's thrombasthenia were easily detectable with this assay. This permits the diagnosis of these disorders on 200 microliters of whole blood within 2 h of blood sampling.
DOI：
--
发表时间：
1980
期刊：
Progress in hemostasis and thrombosis
影响因子：
--
作者：
Phillips,DR
通讯作者：
Phillips,DR
DOI：
10.1172/jci109983
发表时间：
1980-12
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
R. McEver;N. Baenziger;P. Majerus
通讯作者：
R. McEver;N. Baenziger;P. Majerus
冯维勒布兰德因子的单克隆抗体：与猪和人抗原的反应性。
影响因子：
20.3
作者：
Katzmann,JA;Mujwid,DK;Miller,RS;Fass,DN
通讯作者：
Fass,DN