Alzheimer's disease: new diagnostic and therapeutic tools.
Alzheimer's disease: new diagnostic and therapeutic tools.
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DOI：
10.1186/1742-4933-5-7
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发表时间：
2008-08-13
期刊：
影响因子：
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通讯作者：
Scapagnini G
中科院分区：
文献类型：
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作者：
Racchi M;Uberti D;Govoni S;Memo M;Lanni C;Vasto S;Candore G;Caruso C;Romeo L;Scapagnini G
2008年3月19日，在意大利巴勒莫举行了老龄化和与年龄相关疾病的病理生理学研讨会。在这里，总结了M.racchi关于阿尔茨海默病生物标志物的历史和未来前景的演讲，以及G.Scapagniti关于细胞应激反应和大脑老化的演讲。阿尔茨海默病(AD)是一种异质性和进行性神经退行性疾病，在西方社会是临床痴呆的主要原因。AD预防是正在进行的研究的重要目标。为了使预防可行，必须实现两个目标：i)在最早的症状变得明显之前，需要确定AD的高危个体，到那时，已经发生了广泛的神经变性，预防疾病的干预可能不那么成功；ii)需要开发安全有效的干预措施，以减少这种病理的表达。总体而言，这里回顾的数据强烈表明，血细胞中构象变化的p53的测量具有很高的区分AD病例与正常衰老、帕金森病和其他痴呆的能力。另一方面，有关姜黄素参与恢复细胞内稳态和重新平衡氧化还原平衡的现有数据表明，姜黄素可能是治疗以炎症为特征的神经退行性疾病的有用辅助药物，如阿尔茨海默病。
On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lectures of M. Racchi on History and future perspectives of Alzheimer Biomarkers and of G. Scapagnini on Cellular Stress Response and Brain Ageing are summarized. Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease, which in Western society mainly accounts for clinica dementia. AD prevention is an important goal of ongoing research. Two objectives must be accomplished to make prevention feasible: i) individuals at high risk of AD need to be identified before the earliest symptoms become evident, by which time extensive neurodegeneration has already occurred and intervention to prevent the disease is likely to be less successful and ii) safe and effective interventions need to be developed that lead to a decrease in expression of this pathology. On the whole, data here reviewed strongly suggest that the measurement of conformationally altered p53 in blood cells has a high ability to discriminate AD cases from normal ageing, Parkinson's disease and other dementias. On the other hand, available data on the involvement of curcumin in restoring cellular homeostasis and rebalancing redox equilibrium, suggest that curcumin might be a useful adjunct in the treatment of neurodegenerative illnesses characterized by inflammation, such as AD.