The consolidation of object and context recognition memory involve different regions of the temporal lobe
The consolidation of object and context recognition memory involve different regions of the temporal lobe
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DOI：
10.1101/lm.1028008
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发表时间：
2008-09-01
影响因子：
2
通讯作者：
Bermudez-Rattoni, Federico
中科院分区：
文献类型：
--
作者：
Balderas, Israela;Rodriguez-Ortiz, Carlos J.;Bermudez-Rattoni, Federico
这些实验研究了几个颞叶区域在巩固识别记忆中的参与情况。茴香霉素，一种蛋白质合成抑制剂，注入海马，嗅周皮质，岛叶皮质，或基底外侧杏仁核的大鼠后立即样品阶段的对象或对象的上下文识别记忆训练。茴香霉素注入到嗅周或岛叶皮质阻断长期（24小时），但不是短期（90分钟）的对象识别记忆。注入海马体或杏仁核不会损害物体识别记忆。茴香霉素注入海马阻断了长期的，但不是短期的对象在上下文识别记忆，而注入到嗅周皮层，岛叶皮层，或杏仁核不影响对象在上下文识别记忆。这些结果清楚地表明，颞叶的不同区域在长期的对象和对象在上下文识别记忆中的差异。而嗅周和岛叶皮层是巩固熟悉的物体所必需的，海马是巩固识别记忆的上下文信息所必需的。总之，这些结果表明，颞叶结构的差异参与再认记忆巩固。
These experiments investigated the involvement of several temporal lobe regions in consolidation of recognition memory. Anisomycin, a protein synthesis inhibitor, was infused into the hippocampus, perirhinal cortex, insular cortex, or basolateral amygdala of rats immediately after the sample phase of object or object-in-context recognition memory training. Anisomycin infused into perirhinal or insular cortices blocked long-term (24 h), but not short-term (90 min) object recognition memory. Infusions into the hippocampus or amygdala did not impair object recognition memory. Anisomycin infused into the hippocampus blocked long-term, but not short-term object-in-context recognition memory, whereas infusions administered into the perirhinal cortex, insular cortex, or amygdala did not affect object-in-context recognition memory. These results clearly indicate that distinct regions of the temporal lobe are differentially involved in long-term object and object-in-context recognition memory. Whereas perirhinal and insular cortices are required for consolidation of familiar objects, the hippocampus is necessary for consolidation of contextual information of recognition memory. Altogether, these results suggest that temporal lobe structures are differentially involved in recognition memory consolidation.