microRNA-126 suppresses PAK4 expression in ovarian cancer SKOV3 cells
microRNA-126 suppresses PAK4 expression in ovarian cancer SKOV3 cells
复制标题
microRNA-126抑制卵巢癌SKOV3细胞中PAK4的表达
DOI：
10.3892/ol.2015.3012
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发表时间：
2015-05-01
期刊：
影响因子：
2.9
通讯作者：
Zhang, Weijiang
中科院分区：
文献类型：
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作者：
Luo, Ping;Fei, Jing;Zhang, Weijiang
原发性卵巢癌是妇科癌症死亡的主要原因之一。抑制丝氨酸/苏氨酸p21激活的蛋白(PAKs)，参与细胞形态和细胞骨架重组，已被假设为改善卵巢癌患者的生存。然而，microRNA-126(miR-126)和PAK4在抑制卵巢癌细胞侵袭中的相关性仍有待证实。本研究发现，与正常卵巢癌SKOV3细胞相比，miR-126基因突变的卵巢癌SKOV3细胞PAK4表达水平发生了变化。转染LV3-miR-126提高miR-126表达的SKOV3细胞PAK4表达水平显著下调(P
Primary ovarian cancer is one of the predominant causes of mortality from gynecological cancer. The suppression of serine/threonine p21-activated kinases (PAKs), proteins involved in cell morphology and cytoskeletal reorganization, has been hypothesized to improve the survival of patients with ovarian cancer. However, the association between microRNA-126 (miR-126) and PAK4 in the inhibition of ovarian cancer cell invasion remains to be established. The present study demonstrated changes in the level of PAK4 expression in ovarian cancer SKOV3 cells with altered miR-126 compared with normal SKOV3 cells. The SKOV3 cells that were transfected with LV3-miR-126 to increase miR-126 expression exhibited significantly downregulated expression levels of PAK4 (P