Fluid-Attenuated Inversion Recovery Images and Stroke Outcome After Thrombolysis
Fluid-Attenuated Inversion Recovery Images and Stroke Outcome After Thrombolysis
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DOI：
10.1161/strokeaha.111.632026
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发表时间：
2012-02-01
期刊：
影响因子：
8.3
通讯作者：
Fiebach, Jochen B.
中科院分区：
文献类型：
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作者：
Ebinger, Martin;Kufner, Anna;Fiebach, Jochen B.
背景和目的 - 我们调查了动脉和实质中流体衰减反转恢复 (FLAIR) 序列的高信号是否与溶栓后 3 个月的不良预后相关。 方法 - 本研究纳入了在溶栓前和溶栓后 1 天进行 MRI 的连续急性卒中患者，这些患者症状发作时间已知。两名评估者对后续影像学和结果不知情，独立判断是否存在动脉和实质 FLAIR 高信号。 3 个月后评估功能结果（改良 Rankin 量表）。 结果 - 在 90 名患者中，22 名患者存在实质 FLAIR 高信号，42 名患者存在血管高信号。 15 名患者同时出现动脉和实质内 FLAIR 高信号。逐步正向回归分析显示，动脉和实质中 FLAIR 高信号的患者预后较差（改良 Rankin 量表评分 >2）的调整优势比为 14.5（95% 置信区间，1.3-158.5；P=0.03）。结论 - 动脉和实质中 FLAIR 高信号是与不良结局相关的急性缺血性卒中的一个易于使用的 MRI 特征 3 溶栓治疗后数月。 （中风。2012；43：539-542。）
Background and Purpose-We investigated if hyperintensities on fluid-attenuated inversion recovery (FLAIR) sequences in arteries and parenchyma are associated with poor outcome 3 months after thrombolysis.Methods-Consecutive acute stroke patients with known time of symptom onset who had an MRI before and 1 day after thrombolysis were included in this study. Blinded to follow-up imaging and outcome, 2 raters independently judged the presence or absence of arterial and parenchymal FLAIR hyperintensities. Functional outcome (modified Rankin Scale) was assessed after 3 months.Results-Out of 90 patients, 22 had parenchymal FLAIR hyperintensities and 42 had hyperintense vessels. The combination of FLAIR hyperintensities in arteries and parenchyma occurred in 15 patients. Stepwise forward regression analysis revealed an adjusted odds ratio of 14.5 for a worse outcome (modified Rankin Scale score >2) in patients with FLAIR hyperintensities in arteries and parenchyma (95% confidence interval, 1.3-158.5; P=0.03).Conclusions-FLAIR hyperintensities in arteries and parenchyma are an easy-to-use MRI feature in acute ischemic stroke associated with poor outcome 3 months after thrombolysis. (Stroke. 2012;43:539-542.)