Endocarditis due to methicillin-resistant Staphylococcus aureus in rabbits: expression of resistance to beta-lactam antibiotics in vivo and in vitro.
Endocarditis due to methicillin-resistant Staphylococcus aureus in rabbits: expression of resistance to beta-lactam antibiotics in vivo and in vitro.
复制标题
兔耐甲氧西林金黄色葡萄球菌引起的心内膜炎：体内和体外对β-内酰胺抗生素耐药性的表达。
DOI：
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发表时间：
1984
影响因子：
6.4
通讯作者：
M. Sande
中科院分区：
文献类型：
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作者：
H. Chambers;C. Hackbarth;T. Drake;M. Rusnak;M. Sande
Whether a strain of methicillin-resistant Staphylococcus aureus susceptible to cephalothin by the disk-diffusion method was also susceptible to cephalothin in vivo was evaluated in the rabbit model of endocarditis. Rabbits with aortic-valve endocarditis due to methicillin-resistant S. aureus that were treated for four days with cephalothin had the same numbers of organisms in vegetations as did untreated rabbits. Treatment with cephalothin caused emergence of a highly resistant subpopulation in aortic-valve vegetations. Organisms highly resistant to cephalothin were also highly resistant to nafcillin. Thus broth-dilution and disk-diffusion tests may not predict therapeutic failure for cephalothin against strains of methicillin-resistant S. aureus. Because of cross-resistances among beta-lactam drugs, these strains should be considered uniformly resistant to this general class of antimicrobial agents, regardless of results from these tests.
多重耐药金黄色葡萄球菌：医院感染的引入、传播和演变。
影响因子：
39.2
作者：
Locksley,RM;Cohen,ML;Quinn,TC;Tompkins,LS;Coyle,MB;Kirihara,JM;Counts,GW
通讯作者：
Counts,GW