Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside.
Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside.
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DOI：
10.3389/fphys.2021.606931
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发表时间：
2021
影响因子：
4
通讯作者：
Aizawa Y
中科院分区：
文献类型：
--
作者：
Yamakawa H;Kato TS;Noh JY;Yuasa S;Kawamura A;Fukuda K;Aizawa Y
甲状腺激素（TH）在甲状腺中合成，并在血液中循环，调节体内的细胞、组织和器官。特别是，它们对心血管系统产生多种影响。众所周知，THs 可以提高心率和心肌收缩力，改善心脏的收缩和舒张功能，并降低全身血管阻力。在过去的30年里，一些研究人员研究了介导TH在心血管系统中作用的分子途径，以更好地了解其作用机制。 TH 对心肌细胞的影响有两种机制，即基因组途径和非基因组途径。在这篇综述中，我们总结了目前对THs在心功能中的作用、其临床表现和血流动力学参数以及甲状腺功能亢进或甲状腺功能减退相关心脏病患者的治疗原则的认识。我们还描述了诱发甲状腺功能障碍的心血管药物，并解释了胺碘酮甲状腺毒性的机制，胺碘酮被认为是最有效的抗心律失常药物。最后，我们讨论了最近关于甲状腺激素参与调节成人心脏心肌再生和代谢的报道。
Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood to regulate cells, tissues, and organs in the body. In particular, they exert several effects on the cardiovascular system. It is well known that THs raise the heart rate and cardiac contractility, improve the systolic and diastolic function of the heart, and decrease systemic vascular resistance. In the past 30 years, some researchers have studied the molecular pathways that mediate the role of TH in the cardiovascular system, to better understand its mechanisms of action. Two types of mechanisms, which are genomic and non-genomic pathways, underlie the effects of THs on cardiomyocytes. In this review, we summarize the current knowledge of the action of THs in the cardiac function, the clinical manifestation and parameters of their hemodynamics, and treatment principles for patients with hyperthyroid- or hypothyroid-associated heart disease. We also describe the cardiovascular drugs that induce thyroid dysfunction and explain the mechanism underlying the thyroid toxicity of amiodarone, which is considered the most effective antiarrhythmic agent. Finally, we discuss the recent reports on the involvement of thyroid hormones in the regulation of myocardial regeneration and metabolism in the adult heart.
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影响因子：
37.8
作者：
Baumgartner C;da Costa BR;Collet TH;Feller M;Floriani C;Bauer DC;Cappola AR;Heckbert SR;Ceresini G;Gussekloo J;den Elzen WPJ;Peeters RP;Luben R;Völzke H;Dörr M;Walsh JP;Bremner A;Iacoviello M;Macfarlane P;Heeringa J;Stott DJ;Westendorp RGJ;Khaw KT;Magnani JW;Aujesky D;Rodondi N;Thyroid Studies Collaboration
通讯作者：
Thyroid Studies Collaboration
影响因子：
5.8
作者：
Biondi, B;Palmieri, EA;Perticone, F
通讯作者：
Perticone, F
影响因子：
4.7
作者：
Biondi, Bernadette;Bartalena, Luigi;Kahaly, George J.
通讯作者：
Kahaly, George J.
影响因子：
120.7
作者：
Cappola, AR;Fried, LP;Ladenson, PW
通讯作者：
Ladenson, PW
影响因子：
5.8
作者：
Cappola, AR;Ladenson, PW
通讯作者：
Ladenson, PW