N-Heterocyclic Carbene-Catalyzed [4+2] Cyclization of Saturated Carboxylic Acid with o-Quinone Methides through in Situ Activation: Enantioselective Synthesis of Dihydrocoumarins
N-Heterocyclic Carbene-Catalyzed [4+2] Cyclization of Saturated Carboxylic Acid with o-Quinone Methides through in Situ Activation: Enantioselective Synthesis of Dihydrocoumarins
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N-杂环卡宾催化[4 2]饱和羧酸与邻醌甲基化物的原位活化环化：对映选择性合成二氢香豆素
DOI：
10.1021/acs.joc.6b02444
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发表时间：
2017
影响因子：
3.6
通讯作者：
Yao Changsheng
中科院分区：
文献类型：
--
作者：
Wang Yuanfeng;Pang Jian;Dong Jingjiao;Yu Chenxia;Li Tuanjie;Wang Xiang-Shan;Shen Shide;Yao Changsheng
以饱和羧酸和醌甲基化物为原料，采用原位活化的方法，实现了N-杂环卡宾（NHC）催化的二氢香豆素缩[4 + 2]醛的合成.该方案导致优异的非对映选择性和对映选择性以及良好的产率，并且使用容易获得且廉价的起始材料。
AnN-heterocyclic carbene (NHC)-catalyzed formal [4 + 2] synthesis of dihydrocoumarins was realized from saturated carboxylic acids ando-quinone methides via an in situ activation strategy. This protocol results in excellent diastereoselectivity and enantioselectivity and good yields and uses readily available and inexpensive starting materials.