Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin
Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin
复制标题
DOI：
10.1016/s0960-894x(01)00567-4
复制
发表时间：
2001-10-22
影响因子：
2.7
通讯作者：
Ziegler, CB
中科院分区：
文献类型：
--
作者：
Sakya, SM;Suarez-Contreras, M;Ziegler, CB
3-合成了硫代特窗酸天然产物硫乳霉素的乙酰基类似物，并对其进行了抗家畜病原体的研究。一些类似物对金黄色葡萄球菌的活性优于硫乳霉素，对多杀性巴氏杆菌的活性相当。几种半合成修饰的硫代乳霉素类似物的活性与硫代乳霉素相比没有改善。(C)2001爱思唯尔科技有限公司版权所有。
3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycin against Staphylococcus aureus and comparable activity against Pasteurella multocida. Several semisynthetically modified analogues of thiolactomycin showed no improvement in activity over thiolactomycin. (C) 2001 Elsevier Science Ltd. All rights reserved.