Strong and significant relationships between aggregation of major coronary risk factors and the acceleration of carotid atherosclerosis in the general population of a Japanese city -: The Suita Study
Strong and significant relationships between aggregation of major coronary risk factors and the acceleration of carotid atherosclerosis in the general population of a Japanese city -: The Suita Study
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DOI：
10.1001/archinte.160.15.2297
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发表时间：
2000-08-14
影响因子：
--
通讯作者：
Ogata, J
中科院分区：
文献类型：
--
作者：
Mannami, T;Baba, S;Ogata, J
背景：通过高分辨率 B 型超声检查测量的颈动脉内膜中层厚度 (IMT) 已被用作测量动脉粥样硬化进展的无创替代终点。然而，冠状动脉危险因素聚集与颈动脉粥样硬化形成之间的关系尚无详细数据。高分辨率超声检查检测到的颈动脉粥样硬化与年龄和性别主要冠状动脉危险因素整合之间关系的横断面评估。年龄在30岁至86岁之间的受试者是从位于日本第二大城市大阪的吹田市随机抽取的，其中男性1896人，女性2102人。颈动脉粥样硬化的评估方法包括：IMT 动脉粥样硬化指数、斑块数量、斑块评分以及超声检查颈动脉狭窄百分比，按性别和年龄组按主要冠状动脉危险因素（即高血压[舒张压大于或等于 90 mm Hg 和/或收缩压大于或等于 140 mm Hg 或正在接受药物治疗]、吸烟[当前吸烟者]、和高胆固醇血症[血清总胆固醇水平大于或等于5.68 mmol/L [220 mg/dL]或正在接受药物治疗]）。结果：具有1个主要冠状动脉危险因素的受试者的平均颈动脉粥样硬化指数值，特别是平均IMT值，比没有主要冠状动脉危险因素的受试者平均高0.028毫米（3.2%），女性平均高0.025毫米（2.9%）冠状动脉危险因素；对于具有 2 个危险因素的受试者，男性高出 0.054 毫米（6.3%），女性高出 0.053 毫米（6.2%）；对于具有 3 个主要危险因素的高危受试者，男性高出 0.135 毫米（15.8%），女性高出 0.137 毫米（15.4%）。严重狭窄至少50%的受试者比例随着冠状动脉危险因素数量的增加而逐步增加，并表现出显着差异（P
Background: Carotid arterial intimal-medial thickness (IMT) measured by high-resolution B-mode ultrasonography has come to be used as a noninvasive surrogate end point to measure progression of atherosclerosis. However, there are no detailed data on the relationship between aggregation of coronary risk factors and carotid atherogenesis.Methods; Cross-sectional assessment of the relationship between carotid atherosclerosis detected by high-resolution ultrasonography and integration of major coronary risk factors by age and sex. Subjects aged 30 to 86 years were randomly selected from Suita, located in Osaka, the second largest urban area of Japan, including 1896 men and 2102 women. Carotid atherosclerosis was evaluated by using our atherosclerotic indexes of IMT, plaque number, plaque score, and percentage of stenosis of the carotid artery assessed using ultrasonography by sex and age group classified by number of major coronary risk factors (ie, hypertension [diastolic blood pressure greater than or equal to 90 mm Hg and/or systolic blood pressure greater than or equal to 140 mm Hg or receiving medication], smoking [current smoker], and hypercholesterolemia [serum total cholesterol level greater than or equal to 5.68 mmol/L [220 mg/dL] or receiving medication]).Results: The mean carotid atherosclerotic index value, especially the mean IMT value, of the subjects with 1 major coronary risk factor was on average 0.028 mm (3.2%) higher for men and 0.025 mm (2.9%) higher for women than that of the subjects without major coronary risk factors; for subjects with 2 risk factors, 0.054 mm (6.3%) higher for men and 0.053 mm (6.2%) higher for women; and for high-risk subjects with 3 major risk factors, 0.135 mm (15.8%) higher for men and 0.137 mm (15.4%) higher for women. The percentage of the subjects with severe stenosis of at least 50% increased stepwise with increases in the number of coronary risk factors and showed a significant difference (P