Neuropsychological and psychiatric functioning pre- and posthematopoietic stem cell transplantation in adult cancer patients: A preliminary study
Neuropsychological and psychiatric functioning pre- and posthematopoietic stem cell transplantation in adult cancer patients: A preliminary study
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DOI：
10.1017/s1355617707070208
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Gingrich, Roger
中科院分区：
文献类型：
--
作者：
Beglinger, Leigh J.;Duff, Kevin;Gingrich, Roger
目前的研究特点的认知和精神状态的造血干细胞移植（HSCT）患者移植前后不久。30例成年患者在移植前1-2周和移植后100天进行了前瞻性的神经心理和精神测量评估。移植前，参与者在多项神经心理学指标上表现出轻度损伤，其中学习和注意力方面的表现最差。与正常数据相比，精神功能显著升高。然而，在移植后100天观察到神经心理学指标的显着改善。抑郁和焦虑的分数也有所改善。HSCT的候选人在手术前经历了轻度的弥漫性认知功能障碍和精神疾病，但在这个小样本中，这些症状在移植后3个月显著改善。关于这些可能的移植前后遗症和反弹的可能性的教育可能有助于患者和家庭为这种治疗和恢复期做准备。
The current study characterizes cognitive and psychiatric status in hematopoietic stem cell transplantation (HSCT) patients shortly before and after transplant. Thirty adult patients were assessed prospectively 1-2 weeks before transplantation and 100 days posttransplantation on neuropsychological and psychiatric measures. Before transplant, participants showed mild impairments on several neuropsychological measures, with the poorest performances occurring on learning and attention. Psychiatric functioning was significantly elevated compared with normative data. Significant improvements, however, were observed on neuropsychological measures by 100 days after transplant. Depression and anxiety scores also improved. Candidates for HSCT experienced mild diffuse cognitive dysfunction and psychiatric morbidity before the procedure, but these symptoms significantly improved by 3 months following their transplant in this small sample. Education about these possible pretransplant sequelae and the potential for rebound may be helpful to patients and families as they prepare for this treatment and the recovery period.