Reconstruction of an average cortical column in silico
Reconstruction of an average cortical column in silico
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DOI：
10.1016/j.brainresrev.2007.07.011
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发表时间：
2007-10-01
影响因子：
--
通讯作者：
Sakmann, B.
中科院分区：
文献类型：
--
作者：
Helmstaedter, M.;de Kock, C. P. J.;Sakmann, B.
高尔基和卡哈尔对单个神经元的描述是世纪来神经解剖学的基础。一个新的挑战是在细胞分辨率下解剖学地描述可以驱动行为的完整局部电路。在这篇文章中，我们审查的可能性，以获得一个模型皮质柱使用在体外和体内对录音，然后通过解剖重建的投影和靶细胞。这些对建立连接模块，最终可能是有用的，以合成一个平均的大脑皮层柱。与在体内测量的感觉诱发神经元活动的数据一起，这将允许基于比以前尝试的更现实的假设来建模行为的解剖和功能细胞基础。(C)2007 Elsevier B.V.保留所有权利。
The characterization of individual neurons by Golgi and Cajal has been the basis of neuroanatomy for a century. A new challenge is to anatomically describe, at cellular resolution, complete local circuits that can drive behavior. In this essay, we review the possibilities to obtain a model cortical column by using in vitro and in vivo pair recordings, followed by anatomical reconstructions of the projecting and target cells. These pairs establish connection modules that eventually may be useful to synthesize an average cortical column in silico. Together with data on sensory evoked neuronal activity measured in vivo, this will allow to model the anatomical and functional cellular basis of behavior based on more realistic assumptions than previously attempted. (C) 2007 Elsevier B.V. All rights reserved.