Male gender and not the severity of hypertension is associated with end-organ damage in aged stroke-prone spontaneously hypertensive rats
Male gender and not the severity of hypertension is associated with end-organ damage in aged stroke-prone spontaneously hypertensive rats
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DOI：
10.1016/j.amjhyper.2004.12.014
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发表时间：
2005-06-01
影响因子：
3.2
通讯作者：
Stier, CT
中科院分区：
文献类型：
--
作者：
Masineni, SN;Chander, PN;Stier, CT
背景：众所周知，性别影响肾衰竭的进展。男性患者比女性表现出更快的年龄依赖性肾病的发展。在本研究中，我们研究了动脉血压（BP），蛋白尿，和终末器官损伤的男性和女性退休育种从我们的群体中风倾向的自发性高血压大鼠（SHRSP）。方法：男性（n = 7）和女性（n = 11）SHRSP同窝仔维持在普瑞纳实验室周5008和水进行了研究，在53周龄开始。通过尾袖体积描记法测量收缩压，并定量24小时尿蛋白排泄，同时将动物圈养在代谢笼中。通过眶后出血获得血液。然后通过无线电遥测监测平均动脉压（MAP）。器官保存组织病理学assessment.Results：尾袖收缩压没有性别差异。男性SHRSP的蛋白尿（128 +/- 7 mg/d）高于女性（21 +/- 5 mg/d，P
Background: It is well-known that gender affects the progression of kidney failure. Male patients exhibit faster development of age-dependent renal disease than do women. In the present study, we examined arterial blood pressure (BP), proteinuria, and end-organ damage in male and female retired breeders from our colony of stroke-prone spontaneously hypertensive rats (SHRSP).Methods: Male (n = 7) and female (n = 11) SHRSP littermates maintained on Purina Laboratory Chow 5008 and water were studied starting at 53 weeks of age. Systolic BP was measured by tail-cuff plethysmography and 24-h urinary protein excretion was quantified while animals were housed in metabolic cages. Blood was obtained by retro-orbital bleeding. Mean arterial pressure (MAP) was then monitored by radiotelemetry. Organs were preserved for histopathologic assessment.Results: Tail-cuff systolic BP did not differ between the sexes. Male SHRSP exhibited greater proteinuria (128 +/- 7 mg/d) than females (21 +/- 5 mg/d, P