Recovery of the human compound action potential following prior stimulation
Recovery of the human compound action potential following prior stimulation
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DOI：
10.1016/s0378-5955(98)00136-1
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发表时间：
1998-10-01
期刊：
影响因子：
2.8
通讯作者：
Relkin, EM
中科院分区：
文献类型：
--
作者：
Murnane, OD;Prieve, BA;Relkin, EM
在四名听力正常的人类受试者中，使用前掩蔽刺激范例测量复合动作电位（CAP）从先前刺激的恢复。使用放置在鼓膜上的芯电极记录CAP。4000 Hz，97 dB SPL条件刺激CAP振幅响应于4000 Hz探头的影响进行了测量，作为一个功能的条件探头间隔为三个探头水平。在1359 ms的平均调节器-探针间隔下，标准化探针响应幅度完全恢复到对照值，类似于在栗鼠中观察到的（Relkin，E.M.，Doucet，J.R.，S.，A.，1995.先前刺激后复合动作电位的恢复：反映低自发性罕见听觉神经元恢复的缓慢成分的证据。Res. 83，183-189）。本结果被解释为低自发速率（SR）、高阈值神经元从先前刺激缓慢恢复的结果（Relkin，E.M.，Doucet，J.R.，1991.从先前刺激中恢复。I：与初级听觉神经元自发放电率的关系。听Res.55，215-222），并且可以为人类中存在一类低SR听觉神经元提供间接生理学证据。(C)1998年由Elsevier Science B. V.出版，版权所有。
The recovery from prior stimulation of the compound action potential (CAP) was measured using a forward masking stimulus paradigm in four normal-hearing, human subjects. The CAP was recorded using a wick electrode placed on the tympanic membrane. The effects of a 4000-Hz, 97-dB SPL conditioning stimulus on CAP amplitude in response to a 4000-Hz probe were measured as a function of conditioner-probe interval for three probe levels. The normalized probe response amplitude was completely recovered to the control values at an average conditioner-probe interval of 1359 ms, similar to that observed in chinchilla (Relkin, E.M., Doucet, J.R., Sterns, A., 1995. Recovery of the compound action potential following prior stimulation: evidence for a slow component that reflects recovery of low spontaneous-rare auditory neurons, Hear. Res. 83, 183-189). The present results are interpreted as a consequence of the slow recovery of low spontaneous-rate (SR), high threshold neurons from prior stimulation (Relkin, E.M., Doucet, J.R., 1991. Recovery from prior stimulation. I: Relationship to spontaneous firing rates of primary auditory neurons. Hear. Res. 55, 215-222) and may provide indirect physiological evidence for the existence of a class of low-SR auditory neurons in humans. (C) 1998 Published by Elsevier Science B.V. All rights reserved.