Toxicity of hemorrhagic ascitic fluid associated with hemorrhagic pancreatitis.
Toxicity of hemorrhagic ascitic fluid associated with hemorrhagic pancreatitis.
复制标题
与出血性胰腺炎相关的出血性腹水的毒性。
DOI：
10.1001/archsurg.1982.01380280007002
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发表时间：
1982
影响因子：
--
通讯作者：
T. Pullos
中科院分区：
文献类型：
--
作者：
C. Frey;H. N. Wong;D. Hickman;T. Pullos
通过胰管逆行灌注牛磺胆酸钠和胰蛋白酶的混合物，在犬中诱导出血性胰腺炎。13只犬中有7只接受了抗生素预处理。将从犬腹腔回收的出血性腹水（HAF）以2.5、5、10、15和20 mL的体积腹腔内注射到小鼠中。根据接受的HAF是否来自给予抗生素的狗，将小鼠分为两组。小鼠的死亡率与注射HAF的体积成正比。接受无菌HAF的小鼠的死亡率在20 mL时为79.4%，在15 mL时为55.8%，在10 mL时为29.4%，在5 mL时为26%，在2.5 mL时为17%。接受25 mL和生理盐水溶液的小鼠中无死亡，接受20 mL犬血浆的小鼠中死亡率为15%。
Hemorrhagic pancreatitis was induced in dogs by a retrograde infusion of the pancreatic duct with a mixture of taurocholate sodium and trypsin. Seven of the 13 dogs were pretreated with antibiotics. The hemorrhagic ascitic fluid (HAF) recovered from the dogs' abdomens was injected intraperitoneally into mice in volumes of 2.5, 5, 10, 15, and 20 mL. The mice were divided into two groups depending on whether the HAF received was from dogs given antibiotics. The mortality among the mice was proportional to the volume of HAF injected. The mortality among mice receiving the sterile HAF was 79.4% at 20 mL, 55.8% at 15 mL, 29.4% at 10 mL, 26% at 5 mL, and 17% at 2.5 mL. There were no deaths among mice receiving 25 mL and saline solution and the mortality was 15% among mice receiving 20 mL of dog plasma.