Differential FDDNP PET Patterns in Nondemented Middle-Aged and Older Adults
Differential FDDNP PET Patterns in Nondemented Middle-Aged and Older Adults
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DOI：
10.1097/jgp.0b013e318198750b
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发表时间：
2009-05-01
影响因子：
7.2
通讯作者：
Small, Gary W.
中科院分区：
文献类型：
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作者：
Ercoli, Linda M.;Siddarth, Prabha;Small, Gary W.
目的：作者探讨了使用2-（1-{6-[（2-[氟-18]氟乙基）（甲基）氨基]-2-萘基}亚乙基）丙二腈（FDDNP）（一种在体外与斑块和缠结结合的分子）进行的正电子发射断层扫描（PET）是否可以识别患有轻度认知障碍（MCI）或认知正常的中老年人的同质亚组。对象：五十六例受试者（轻度认知障碍，N = 29;认知正常，N = 27）。测量：进行FDDNP-PET扫描。Logan参数图像使用小脑作为参考区域产生，并且获得已知在阿尔茨海默病（AD）中积累斑块和缠结的感兴趣区域（ROI）的相对分布体积。聚类分析用于根据FDDNP信号分布确定受试者亚组。一旦确定了FDDNP集群，作者随后还在诊断和认知测试表现方面对集群进行了表征，并对这些变量的集群差异进行了分析。结果如下：作者确定了三个FDDNP簇：颞侧和后扣带回ROI中的高信号（颞-后扣带回HT/PC高）;所有ROI中的低信号（低全局[LG]簇）;额叶和顶叶高信号伴颞和后扣带回信号（HF/PA）。大多数MCI受试者属于HT/PC和HF/PA簇，而大多数认知正常受试者属于LG簇。在认知测试中，HT/PC和HF/PA集群的表现明显不如LG，但彼此之间没有显着差异。结论：这种方法可能是有用的，在确定潜在的高风险成像集群模式。将进行纵向随访，以确定这些亚组与诊断和功能结局的相关性。(Am J Geriatr Psychiatry 2009; 17：397-406）
Objective: The authors explored whether positron emission tomography (PET) with 2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl) amino]-2-naphthyl} ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles in vitro, might identify homogeneous subgroups of persons in middle-aged and older persons with mild cognitive impairment (MCI) or normal cognition. Participants: Fifty-six subjects (MCI, N = 29; normal cognition, N = 27). Measurements: FDDNP-PET scans were performed. Logan parametric images were produced using cerebellum as a reference region, and relative distribution volumes were obtained for regions of interest (ROIs) known to accumulate plaques and tangles in Alzheimer disease (AD). Cluster analysis was used to identify subgroups of subjects according to FDDNP signal distribution. Once the FDDNP clusters were identified, the authors then characterized the clusters also with respect to diagnosis and cognitive test performances and conducted analyses on cluster differences in these variables. Results: The authors identified three FDDNP clusters: high signal in lateral temporal and posterior cingulate ROIs (high temporal-posterior cingulate HT/PC); low signal in all ROIs (low global [LG] cluster); high frontal and parietal signal with intermediate temporal and posterior cingulate signal (HF/PA). Most MCI subjects belonged to the HT/PC and HF/PA clusters, whereas most cognitively normal subjects were in the LG cluster. On cognitive tests, the HT/PC and the HF/PA clusters performed significantly worse than LG but did not significantly differ from each other. Conclusions: This approach may be useful in identifying potential high-risk imaging cluster patterns. Longitudinal follow-up would be performed to determine the association of these subgroups with diagnostic and functional outcome. (Am J Geriatr Psychiatry 2009; 17: 397-406)