Free-breathing, non-ECG, continuous myocardial T1 mapping with cardiovascular magnetic resonance multitasking
Free-breathing, non-ECG, continuous myocardial T1 mapping with cardiovascular magnetic resonance multitasking
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DOI：
10.1002/mrm.27574
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发表时间：
2019-04-01
影响因子：
3.3
通讯作者：
Christodoulou, Anthony G.
中科院分区：
文献类型：
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作者：
Shaw, Jaime L.;Yang, Qi;Christodoulou, Anthony G.
目的：评估一种自由呼吸、非心电图（ECG）、连续心肌T-1和细胞外容积（ECV）标测技术的准确性和可重复性，该技术适用于Multitasking framework.Methods：Multitasking framework采用自由呼吸、非ECG、连续采集T-1标测方法来量化心肌固有T-1和ECV。我们采集交错的高空间分辨率的图像数据和高时间分辨率的辅助数据后，反转恢复脉冲在设定的时间间隔和执行低秩张量成像重建图像在344反转时间，20个心脏相位，和6个呼吸相位。多任务T-1映射在生成本地的T-1和ECV地图的准确性和可重复性进行了比较，与传统的技术在一个幻影，模拟，12名健康受试者，和10例急性心肌梗死patients.Results：在幻影，多任务T-1映射强烈相关的金标准自旋回波反转恢复（R-2 = 0.99）。一项模拟研究表明，多任务T-1标测具有与完全采样地面实况相似的心肌清晰度。来自多任务T-1标测的体内天然T-1和ECV值与常规MOLLI值吻合良好，并且对于60秒、30秒或15秒的数据，天然T-1和ECV标测显示出良好的可重复性。结论：多任务T-1标测技术可在自由呼吸、无ECG、连续扫描、图像质量好、可重复性好的条件下定量测定正常人心肌组织的T-1和ECV，并与急性心肌梗死患者的MOLLI T-1和ECV相关。
Purpose: To evaluate the accuracy and repeatability of a free-breathing, non-electrocardiogram (ECG), continuous myocardial T-1 and extracellular volume (ECV) mapping technique adapted from the Multitasking framework.Methods: The Multitasking framework is adapted to quantify both myocardial native T-1 and ECV with a free-breathing, non-ECG, continuous acquisition T-1 mapping method. We acquire interleaved high-spatial resolution image data and high-temporal resolution auxiliary data following inversion-recovery pulses at set intervals and perform low-rank tensor imaging to reconstruct images at 344 inversion times, 20 cardiac phases, and 6 respiratory phases. The accuracy and repeatability of Multitasking T-1 mapping in generating native T-1 and ECV maps are compared with conventional techniques in a phantom, a simulation, 12 healthy subjects, and 10 acute myocardial infarction patients.Results: In phantoms, Multitasking T-1 mapping correlated strongly with the gold-standard spin-echo inversion recovery (R-2 = 0.99). A simulation study demonstrated that Multitasking T-1 mapping has similar myocardial sharpness to the fully sampled ground truth. In vivo native T-1 and ECV values from Multitasking T-1 mapping agree well with conventional MOLLI values and show good repeatability for native T-1 and ECV mapping for 60 seconds, 30 seconds, or 15 seconds of data. Multitasking native T-1 and ECV in myocardial infarction patients correlate positively with values from MOLLI.Conclusion: Multitasking T-1 mapping can quantify native T-1 and ECV in the myocardium with free-breathing, non-ECG, continuous scans with good image quality and good repeatability in vivo in healthy subjects, and correlation with MOLLI T-1 and ECV in acute myocardial infarction patients.