Bioactive Proteins in Human Milk: Health, Nutrition, and Implications for Infant Formulas
Bioactive Proteins in Human Milk: Health, Nutrition, and Implications for Infant Formulas
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DOI：
10.1016/j.jpeds.2016.02.070
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发表时间：
2016-06-01
影响因子：
5.1
通讯作者：
Lonnerdal, Bo
中科院分区：
文献类型：
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作者：
Lonnerdal, Bo
母乳对新生儿和发育中的婴儿有很多好处。与配方奶喂养的婴儿相比，母乳喂养的婴儿有更好的长期结果，例如减少肥胖、糖尿病和心血管疾病，这一点得到了充分的支持。更多的短期结果，例如疾病的发生率和持续时间、营养状况以及生命第一年的认知发展也证明了母乳喂养的好处。母乳中的多种蛋白质，包括乳铁蛋白、α-乳清蛋白、乳脂球膜蛋白和骨桥蛋白，已被证明具有从参与预防感染到从母乳中获取营养的生物活性。在某些情况下，这些蛋白质的牛对应物发挥相似的生物活性。通过乳制品技术，可以将富含这些蛋白质的蛋白质级分添加到婴儿配方奶粉中。
Breast milk confers many benefits to the newborn and developing infant. There is substantial support for better long-term outcomes, such as less obesity, diabetes, and cardiovascular disease, in breastfed compared with formula-fed infants. More short-term outcomes, such as incidence and duration of illness, nutrient status, and cognitive development during the first year of life also demonstrate benefits of breastfeeding. Several proteins in breast milk, including lactoferrin, alpha-lactalbumin, milk fat globule membrane proteins, and osteopontin, have been shown to have bioactivities that range from involvement in the protection against infection to the acquisition of nutrients from breast milk. In some cases, bovine counterparts of these proteins exert similar bioactivities. It is possible by dairy technology to add protein fractions highly enriched in these proteins to infant formula.