PEDOT nanocomposites mediated dual-modal photodynamic and photothermal targeted sterilization in both NIR I and II window
PEDOT nanocomposites mediated dual-modal photodynamic and photothermal targeted sterilization in both NIR I and II window
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PEDOT 纳米复合材料在 NIR I 和 II 窗口中介导双模态光动力和光热靶向灭菌
DOI：
10.1016/j.biomaterials.2014.10.075
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发表时间：
2015-02-01
期刊：
影响因子：
14
通讯作者：
Zhou, Jing
中科院分区：
文献类型：
--
作者：
Li, Luoyuan;Liu, Yuxin;Zhou, Jing
采用环保的水热法合成了合适的纳米尺寸为17.2 nm、700至1250 nm的宽吸附范围、光热转换效率（eta）为71.1%的PEDOT纳米粒子。由于吲哚菁绿（ICG）与PEDOT之间的静电引力，有效提高了ICG在水溶液中的稳定性。戊二醛（GTA）修饰的PEDOT纳米粒子直接靶向细菌，MU实验证明了PEDOT:ICG@PEG-GTA对不同细菌和细胞的低毒性。在近红外 (NIR) 照射（PDT 为 808 nm，PTT 为 1064 nm）的情况下，使用 PEDOT:ICG@PEG-GTA 进行光动力疗法 (PDT) 和光热疗法 (PTF) 可以有效杀死病原菌。两种不同抑菌方法的组合明显比单独使用 PTT 或 PDT 更有效。所获得的PEDOT:ICG@PEG-GTA可用作光动力和光热联合治疗中的新型协同剂，以在NIR I和II窗口中灭活病原菌。 (C) 2014 Elsevier Ltd. 保留所有权利。
PEDOT nanoparticles with a suitable nanosize of 17.2 nm, broad adsorption from 700 to 1250 nm, and photothermal conversion efficiency (eta) of 71.1%, were synthesized using an environmentally friendly hydrothermal method. Due to the electrostatic attraction between indocyanine green (ICG) and PEDOT, the stability of ICG in aqueous solution was effectively improved. The PEDOT nanoparticles modified with glutaraldehyde (GTA) targeted bacteria directly, and MU experiments demonstrated the low toxicity of PEDOT:ICG@PEG-GTA in different bacteria and cells. Pathogenic bacteria were effectively killed by photodynamic therapy (PDT) and photothermal therapy (PTF) with PEDOT:ICG@PEG-GTA in the presence of near-infrared (NIR) irradiation (808 nm for PDT, and 1064 nm for PTT). The combination of the two different bacteriostatic methods was significantly more effective than PTT or PDT alone. The obtained PEDOT:ICG@PEG-GTA may be used as a novel synergistic agent in combination photodynamic and photothermal therapy to inactivate pathogenic bacteria in both the NIR I and II window. (C) 2014 Elsevier Ltd. All rights reserved.