DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission
DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission
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DOI：
10.1126/science.281.5378.838
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发表时间：
1998-08-07
期刊：
影响因子：
56.9
通讯作者：
Greengard, P
中科院分区：
文献类型：
--
作者：
Fienberg, AA;Hiroi, N;Greengard, P
多巴胺能神经元对前脑发挥主要的调节作用。多巴胺和腺苷3 '，5'-单磷酸调节的磷蛋白（32千道尔顿）（DARPP-32），在所有接受多巴胺能输入的神经元中富集，在多巴胺的反应中转化为有效的蛋白磷酸酶抑制剂。产生含有DARPP-32基因的靶向破坏的小鼠显示出对多巴胺、滥用药物和抗精神病药物的分子、电生理和行为反应的严重缺陷。结果表明DARPP-32在调节多巴胺能神经传递的功效中起核心作用。
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.