Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus
Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus
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DOI：
10.1001/jamaoto.2018.3852
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发表时间：
2019-03-01
影响因子：
7.8
通讯作者：
Zoller, Bengt
中科院分区：
文献类型：
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作者：
Cederroth, Christopher R.;PirouziFard, MirNabi;Zoller, Bengt
重要性目前还没有有效的治疗方法来治疗严重的耳鸣，它影响了1%的人口并降低了生活质量。导致从轻度耳鸣转变为重度耳鸣的因素鲜为人知。在进行遗传分析和确定严重耳鸣的发生机制之前，需要确定其遗传度。目的检查临床上显著的耳鸣是否与遗传因素有关，并评估通过被领养人传播耳鸣的遗传风险。从1964年1月1日到2015年12月31日，从瑞典全国登记的被领养人及其亲生父母和养父母的设计、背景和参与者数据收集，并用于在家庭聚类中分离遗传和环境因素。总共调查了11060名被领养人、19015名养父母和17025名亲生父母。本研究采用队列设计和病例对照研究方法，对收养者耳鸣的遗传和非遗传因素进行研究。主要结果和测量的主要结果是有至少一个受影响的亲生父母的被领养人与没有任何受影响的亲生父母的被收养人发生耳鸣的优势比(OR)。结果共有1029例耳鸣患者(男性440例，占42.8%；平均年龄62[14]岁)。确诊耳鸣患病率为2.2%。被诊断为耳鸣的亲生父母的OR为2.22(95%CI，1.03~4.81)，而被诊断为耳鸣的养父母的OR为1.00(95%CI，0.43~2.32)。平均遗传度为31%(14%)。结论遗传因素与临床上有意义的耳鸣家族聚集性有关，提示从可忽略耳鸣向重度耳鸣的转变可能与遗传因素有关。这些发现可能为未来专注于严重耳鸣的基因分析提供洞察力。
IMPORTANCE No effective treatments are currently available for severe tinnitus, which affects 1% of the population and lowers the quality of life. The factors that contribute to the transition from mild to severe tinnitus are poorly known. Before performing genetic analyses and determining the mechanisms involved in the development of severe tinnitus, its heritability needs to be determined.OBJECTIVES To examine whether clinically significant tinnitus is associated with genetic factors and to evaluate the genetic risk in the transmission of tinnitus using adoptees.DESIGN, SETTING, AND PARTICIPANTS Data from adoptees and their biological and adoptive parents from Swedish nationwide registers were collected from January 1, 1964, to December 31, 2015, and used to separate genetic from environmental factors in familial clustering. In all, 11 060 adoptees, 19 015 adoptive parents, and 17 025 biological parents were investigated. The study used a cohort design and a case-control approach to study genetic and nongenetic factors in tinnitus among adoptees.MAIN OUTCOMES AND MEASURES The primary outcomewas odds ratio (OR) of tinnitus in adoptees with at least 1 affected biological parent compared with adoptees without any affected biological parent using logistic regression. The secondary outcome was OR in adoptees with at least 1 affected adoptive parent compared with adoptees without any affected adoptive parent.RESULTS A total of 1029 patients (440 [42.8%] male; mean [SD] age, 62 [14] years) with tinnitus were identified. The prevalence of diagnosed tinnitus was 2.2%. The OR for tinnitus was 2.22 for adoptees (95% CI, 1.03-4.81) of biological parents diagnosed with tinnitus, whereas the OR was 1.00 (95% CI, 0.43-2.32) for adoptees from adoptive parents diagnosed with tinnitus. Mean (SE) heritability determined using tetrachoric correlations was 31% (14%).CONCLUSIONS AND RELEVANCE The findings suggest that genetic factors are associated with the familial clustering of clinically significant tinnitus with no shared-environment association, revealing that the transition from negligible to severe tinnitus may be associated with genetic factors. These findings may provide insight for future genetic analyses that focus on severe tinnitus.