Correlation of IL-31 gene polymorphisms with susceptibility and clinical recurrence of bladder cancer
Correlation of IL-31 gene polymorphisms with susceptibility and clinical recurrence of bladder cancer
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IL-31基因多态性与膀胱癌易感性及临床复发的相关性
DOI：
10.1007/s10689-017-0060-4
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发表时间：
2018-10-01
期刊：
影响因子：
2.2
通讯作者：
Zhang, Lin
中科院分区：
文献类型：
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作者：
Li, Qin;Tang, Tielong;Zhang, Lin
白细胞介素-31（IL-31）是一种重要的细胞因子，可引起炎症反应，而炎症反应可能是肿瘤的危险因素之一。然而，IL-31与肿瘤之间的相关性数据有限。本研究旨在探讨IL-31基因多态性与膀胱癌易感性及临床预后的关系。我们的研究招募了478名对照，156名非肌肉浸润性膀胱癌（NMIBC）和138名肌肉浸润性膀胱癌（MIBC）患者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测IL-31基因rs7977932和rs 4758680两个单核苷酸多态性（SNP）。结果表明rs 4758680基因A等位基因和CA/AA基因型与膀胱癌易感性相关（P=0.04，OR 1.32，95% CI 1.01-1.72; P=0.02，OR 1.43，95% CI 1.05-1.96），rs7977932的G等位基因可能是吸烟患者较不吸烟患者的保护性因素（P=0.005，OR 0.42，95% CI 0.23-0.76）。rs 4758680基因型CA/AA可能是MIBC患者无复发生存期降低的独立危险因素（P=0.03，OR 2.02，95%CI 1.06 ~ 3.85）。我们的数据表明IL-31基因多态性与膀胱癌相关，rs 4758680可能是MIBC患者复发风险高的独立预测因素。
Interleukin-31 is a crucial cytokine triggering inflammation which could be one of the risk factors of tumors. However, data for correlation between IL-31 and tumors are limited. The purpose of our study was to discuss whether genetic polymorphisms of IL-31 were associated with the susceptibility and clinical outcomes of bladder cancer. Our study enrolled 478 controls, 156 non-muscle-invasive bladder cancer (NMIBC) and 138 muscle-invasive bladder cancer (MIBC) patients. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping two single nucleotide polymorphisms (SNPs) of IL-31 gene including rs7977932 and rs4758680. Our results showed that A allele and CA/AA genotypes of rs4758680 were associated with susceptibility to bladder cancer (P=0.04, OR 1.32, 95% CI 1.01-1.72, and P=0.02, OR 1.43, 95% CI 1.05-1.96, respectively), and G allele of rs7977932 might be a protect factor for tobacco smoking patients compared with non-smoking patients (P=0.005, OR 0.42, 95% CI 0.23-0.76). Furthermore, CA/AA genotypes of rs4758680 might be the independent risk factors for the decreased recurrence-free survival of the patients with MIBC (P=0.03, OR 2.02, 95% CI 1.06-3.85. Our data indicated that polymorphisms of IL-31 are associated with bladder cancer, and rs4758680 could be an independent prediction for MIBC patients with a high risk of recurrence.