Cancer metabolism within tumor microenvironments
Cancer metabolism within tumor microenvironments
复制标题
DOI：
10.1016/j.bbagen.2023.130330
复制
发表时间：
2023-02-17
影响因子：
3
通讯作者：
Osawa, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Aki, Sho;Nakahara, Ryuichi;Osawa, Tsuyoshi
背景：肿瘤微环境可以决定肿瘤的异质性和恶性程度。缺氧、营养缺乏和酸性pH可导致与遗传、表观遗传和代谢改变相关的癌症恶性，促进侵袭和转移。适应极端肿瘤微环境的癌细胞可以逃避细胞死亡和免疫反应。它可以刺激耐药性和复发，导致患者预后不良。因此，研究肿瘤微环境中恶性癌细胞的药物靶点是必要的，但这种治疗方法是有限的。细胞-细胞代谢相互作用也可能导致肿瘤微环境中的癌症恶性。细胞器-细胞器相互作用最近作为新的癌症治疗靶点受到关注，因为它们在肿瘤微环境的代谢适应中发挥重要作用。在这篇综述中，我们概述了（1）肿瘤微环境中的代谢改变，（2）细胞与细胞，（3）细胞器与细胞器的代谢相互作用，并为癌症治疗提供了新的见解。
Background: Tumor microenvironments could determine cancer heterogeneity and malignancy. Hypoxia, nutrition starvation, and acidic pH could contribute to cancer malignancy associated with genetic, epigenetic, and metabolic alterations, promoting invasion and metastasis. Cancer cells adapting to extreme tumor microenvironments could enable evasion of cell death and immune responses. It could stimulate drug resistance and recurrence, resulting in poor patient prognosis. Therefore, investigating druggable targets of the malignant cancer cells within tumor microenvironments is necessary, but such treatments are limited. Cell-cell metabolic interaction may also contribute to cancer malignancy within the tumor microenvironments. Organelle-organelle interactions have recently gained attention as new cancer therapy targets as they play essential roles in the metabolic adaptation to the tumor microenvironment. In this review, we overview (1) metabolic alterations within tumor microenvironments, (2) cell-to-cell, and (3) organelle-to-organelle metabolic interactions, and we add novel insights into cancer therapy.