Qualitative analysis of trace quinolone antibiotics by SERS with fine structure dependent sensitivity
Qualitative analysis of trace quinolone antibiotics by SERS with fine structure dependent sensitivity
复制标题
具有精细结构依赖性灵敏度的 SERS 定性分析痕量喹诺酮类抗生素
DOI：
10.1016/j.saa.2022.121365
复制
发表时间：
2022-05-13
影响因子：
4.4
通讯作者：
Liu，Guo-kun
中科院分区：
文献类型：
--
作者：
Zhang，Ming-zhi;Zhou，Zhi-ming;Liu，Guo-kun
抗生素在日常生活中的广泛使用，造成了全球范围内许多病原体对抗生素产生有效耐药性的情况。滥用或过度使用抗生素会造成严重的环境污染，甚至危害人类健康。众所周知，抗生素的功效（毒性）是由分子结构决定的。因此，高灵敏度和高准确度的结构水平定性分析至关重要。拉曼光谱技术，特别是表面增强拉曼光谱技术（Sers）以指纹识别为特征，已成为环境监测、食品安全等领域必不可少的定性分析工具。除手性外，本研究完成了16种具有细微结构差异的喹诺酮类抗生素的Sers定性痕量分析。灵敏度通过特定抗生素中略有变化的官能团的不同电负性和空间位阻调节一个数量级。精细结构依赖的灵敏度使Sers成为一种强有力的现场监测工具，以控制高毒性抗生素的滥用，从而降低对环境生态和人类社会的后续风险。
Antibiotics are widely used in daily life, which has created a global scenario where many pathogenic organisms have become effectively resistant to antibiotics. The abuse or overuse of antibiotics causes significant environmental pollution and even endangers human health. It is well-known that antibiotics' efficacy (toxicity) is determined by molecular structure. Therefore, structure-level qualitative analysis with high sensitivity and accuracy is vitally important. Characterized by fingerprinting recognition, Raman spectroscopy, especially surface-enhanced Raman spectroscopy (SERS), has become an essential qualitative analysis tool in various fields, such as environmental monitoring and food safety. With the exception of chirality, this study completed the qualitative trace analysis of 16 quinolone antibiotics (QNs) with fine molecular structure differences using SERS. The sensitivity was tuned in by one order of magnitude through the different electronegativity and steric hindrances of the slightly changed functional groups in the specific antibiotics. The fine structure dependent sensitivity enables SERS to be a powerful on-site monitoring tool to control the abuse of antibiotics with high toxicity; thus, decreasing the subsequent risk to the environmental ecology and human society.