A culturally-tailored behavioral intervention trial for alcohol use disorders in three American Indian communities: Rationale, design, and methods
A culturally-tailored behavioral intervention trial for alcohol use disorders in three American Indian communities: Rationale, design, and methods
复制标题
DOI：
10.1016/j.cct.2015.12.010
复制
发表时间：
2016-03-01
影响因子：
2.2
通讯作者：
Buchwald, Dedra
中科院分区：
文献类型：
--
作者：
McDonell, Michael G.;Nepom, Jenny R.;Buchwald, Dedra
背景：在许多美洲印第安人/阿拉斯加原住民（AI/AN）社区中存在不成比例的高酒精使用障碍率，但关于AI/AN人群酒精治疗有效性的信息很少。应急管理是一种干预。对于非法使用药物，当患者通过尿液药物测试表现出戒断时，提供有形的强化（奖励）。作为酒精问题的干预措施，应急管理尚未得到广泛研究，因为直到最近，还没有酒精生物标志物可用来充分验证戒酒。目的：HONOR研究旨在确定文化定制的应急管理干预措施是否对患有酒精使用障碍的AI/ an成人有效。方法：参与者包括400名Al/AN酒精依赖的成年人，他们分别居住在美国西部的一个农村保留区、一个城市社区和一个待定的第三个地点。参与者在随机化之前完成4周的导入阶段，然后进行12周的戒酒应急管理干预，或者在对照组中，参与者接受强化物，无论是否饮酒都参加研究访问。参与者在干预后被随访3个多月。主要研究结果是尿乙基葡萄糖醛酸盐证实戒酒；次要结局包括自我报告的酒精和药物使用情况、艾滋病毒风险行为和自我报告的吸烟情况。讨论：这将是针对人工智能/人工神经网络的最大的随机对照试验，也是针对酒精使用障碍的最大的应急管理研究，从而为人工智能/人工神经网络社区和一般的酒精治疗领域提供重要信息。(C) 2015出版的爱思唯尔公司。
Background: Disproportionately high rates of alcohol use disorders are present in many American Indian/Alaska Native (AI/AN) communities, yet little information exists regarding the effectiveness of alcohol treatments in AI/AN populations. Contingency management is an intervention. for illicit drug use in which tangible reinforcers (rewards) are provided when patients demonstrate abstinence as assessed by urine drug tests. Contingency management has not been widely studied as an intervention for alcohol problems because until recently, no alcohol biomarker has been available to adequately verify abstinence.Aims: The HONOR Study is designed to determine whether a culturally-tailored contingency management intervention is an effective intervention for AI/AN adults who suffer from alcohol use disorders.Methods: Participants include 400 Al/AN alcohol-dependent adults residing in one rural reservation, one urban community, as well as a third site to be decided, in the Western U.S. Participants complete a 4-week lead-in phase prior to randomization, then 12 weeks of either a contingency management intervention for alcohol abstinence, or a control condition where participants receive reinforcers for attending study visits regardless of alcohol use. Participants are then followed for 3-more months post-intervention. The primary study outcome is urinary ethyl glucuronide-confirmed alcohol abstinence; secondary outcomes include self-reported alcohol and drug use, HIV risk behaviors, and self-reported cigarette smoking.Discussion: This will be the largest randomized, controlled trial of any alcohol for AI/ANs and the largest contingency management study targeting alcohol use disorders, thus providing important information to Al/AN communities and the alcohol treatment field in general. (C) 2015 Published by Elsevier Inc.