Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate
Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate
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DOI：
10.1016/j.mri.2006.02.001
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发表时间：
2006-07-01
影响因子：
2.5
通讯作者：
Pui, Ching-Hon
中科院分区：
文献类型：
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作者：
Glass, John O.;Reddick, Wilburn E.;Pui, Ching-Hon
本研究的目的是使用客观的定量磁共振成像（MRI）方法，开发一种计算机辅助检测（CAD）工具，以区分白色物质（WM）高信号，无论是白血病（LE）诱导的化疗或正常的成熟过程中的儿童治疗急性淋巴细胞白血病未经照射。由T1加权、T2加权、质子密度加权和液体衰减反转恢复图像和WM组成的组合MRI集。用基于Kohonen自组织映射（SOM）的神经网络分割分析来自空间标准化图谱的灰质和脑脊液比例体积图。分割的地图进行手动分类，以确定最高强度的WM区域和正常出现的WM区域。在228名儿童中，在四个时间点产生了每次检查中归一化为λ的信号强度差异。第二个Kohonen SOM是训练油的第一次检查数据，并分为正常出现或LE组WM。审查CAD工具中的标签显示患者内的一致性测量值为89.8%（167/186）。CAD工具与两名经过培训的观察者的一致阅读之间的总体一致率为84.1%（535/636），其中训练集的一致率为84.2%（170/202），测试集的一致率为84.1%（365/434）。这些结果表明，微妙的治疗诱导的LE调用是客观和可重复地检测在儿童治疗癌症使用这种CAD的方法，基于油的相对差异定量信号强度测量标准化内的每个检查。(C)2006年爱思唯尔公司All rights reserved.
The purpose of this study was to use objective quantitative magnetic resonance imaging (MRI) methods to develop a computer-aided detection (CAD) tool to differentiate white matter (WM) hyperintensities into either leukoencephalopathy (LE) induced by chemotherapy or normal maturational processes in children treated for acute lymphoblastic leukemia without irradiation. A combined MRI set consisting of T1-weighted, T2-weighted, proton-density-weighted and fluid-attenuated inversion recovery images and WM. gray matter and cerebrospinal fluid proportional volume maps from a spatially normalized atlas were analyzed with a neural network segmentation based on a Kohonen self-organizing map (SOM). Segmented maps were manually classified to identify the most hyperintense WM region and the normal-appearing genu region. Signal intensity differences normalized to the genu within each examination were generated for four time points in 228 children. A second Kohonen SOM was trained oil the first examination data and divided the WM into normal-appearing or LE groups. Reviewing labels from the CAD tool revealed a consistency measure of 89.8% (167 of 186) within patients. The overall agreement between the CAD tool and the consensus reading of two trained observers was 84.1% (535 of 636), with 84.2% (170 of 202) agreement in the training set and 84.1% (365 of 434) agreement in the testing set. These results suggest that subtle therapy-induced LE call be objectively and reproducibly detected in children treated for cancer using this CAD approach based oil relative differences in quantitative signal intensity measures normalized within each examination. (C) 2006 Elsevier Inc. All rights reserved.