Influence of halothane on the interactions of serotonin1A and adenosine A1 receptors with G proteins in rat brain membranes.
Influence of halothane on the interactions of serotonin1A and adenosine A1 receptors with G proteins in rat brain membranes.
复制标题
氟烷对大鼠脑膜中血清素 1A 和腺苷 A1 受体与 G 蛋白相互作用的影响。
DOI：
10.1016/0006-2952(91)90272-7
复制
发表时间：
1991
影响因子：
5.8
通讯作者：
Aronstam,RS
中科院分区：
文献类型：
--
作者：
Martin,DC;Dennison,RL;Introna,RP;Aronstam,RS
The influence of halothane on the interactions of 5-HT1A and adenosine A1 receptors with G proteins was determined by monitoring the guanine nucleotide sensitivity of agonist binding to these receptors. Halothane inhibited the binding of radiolabeled agonists to 5-HT1A and adenosine A1 receptors by up to 30%, but only at concentrations considerably greater than those necessary for the maintenance of the anesthetic state. The sensitivity of high-affinity agonist binding to a guanine nucleotide (guanylyl-5'-imidodiphosphate) was not affected by halothane, indicating no disruption of receptor-G protein coupling. Thus, it appears that the ability of halothane to disrupt receptor-mediated signal transduction by interference with receptor-G protein interactions is receptor specific.
