In vivo detection of striatal dopamine release during reward:: A PET study with [11C]raclopride and a single dynamic scan approach
In vivo detection of striatal dopamine release during reward:: A PET study with [11C]raclopride and a single dynamic scan approach
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DOI：
10.1006/nimg.2002.1121
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发表时间：
2002-08-01
期刊：
影响因子：
5.7
通讯作者：
Syrota, A
中科院分区：
文献类型：
--
作者：
Pappata, S;Dehaene, S;Syrota, A
提出了一种新的简单方法，使用正电子发射计算机断层扫描和[C-11]雷氯普利来检测在有奖赏的努力任务期间纹状体细胞外多巴胺浓度的变化。这种方法的目的是提高检测这些影响的灵敏度。它需要一个单一的动态PET研究，并结合经典的动力学模型和SPM的一般线性模型，以提供统计推断在两个短暂的激活阶段由于内源性多巴胺释放而引起的[C-11]雷氯普利时间-活性曲线的变化。动力学模拟预测，在注射后30分钟和60分钟开始的两个5分钟内，可以检测到100%的多巴胺增加。此外，多巴胺释放对[C-11]雷氯普利时间-活度-曲线的影响不同于脑血流量增加引起的影响。这些模拟曲线被用来构建统计线性模型，并在健康受试者中逐个体素检验这一假设，即多巴胺在意外的货币收益期间在腹侧纹状体释放，而在意外的金钱损失期间不释放。实验结果与预期结果一致，尽管多巴胺释放的影响幅度适中。讨论了这种方法的优点和局限性，以及多巴胺参与奖赏加工的结果的相关性。(C)2002年埃尔塞维尔科学公司(美国)。
A new simple method is proposed to detect, using PET and [C-11]raclopride, changes in striatal extracellular dopamine concentration during a rewarded effortful task. This approach aimed to increase the sensitivity in detection of these effects. It requires a single-dynamic PET study and combines the classic kinetic compartmental model with the general linear model of SPM to provide statistical inference on changes in [C-11]raclopride time-activity curve due to endogenous dopamine release during two short periods of activation. Kinetic simulations predicted that 100% dopamine increase during two 5-min periods starting at 30 and 60 min after the injection can be detected. Moreover the effects of dopamine release on the [C-11]raclopride time-activity-curve are different from those induced by CBF increase. These simulated curves were used to construct the statistical linear model and to test voxel-by-voxel in healthy subjects the hypothesis that dopamine is released in the ventral striatum during periods of unexpected monetary gains, but not during periods of unexpected monetary loss. The experimental results are in line with the expected results although the amplitude of the effects due to dopamine release is moderate. The advantages and the limits of this method as well as the relevance of the results for dopamine involvement in reward processing are discussed. (C) 2002 Elsevier Science (USA).