Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332
Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332
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Simperpenoid A 是一种具有高度功能化环己二烯部分的半萜类化合物，具有宝石丙烷-1,2-二酮和甲酸甲酯基团，来自红树林衍生的简单青霉 MA-332
DOI：
10.1021/acs.orglett.8b00327
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发表时间：
2018-03-02
期刊：
影响因子：
5.2
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
Li, Hong-Lei;Xu, Rui;Wang, Bin-Gui
单萜A（1）是从红树林来源的简青霉（Penicillium simplicissimum）MA-332中分离得到的一种具有高度环己二烯结构（C环）的单萜类化合物。由于高度氧化和官能化的环C和缺乏一些关键的相关性，通过X射线晶体学分析解决了平面结构和立体构型的明确归属。化合物1以纳摩尔量表现出对流感神经氨酸酶的抑制活性。
Simpterpenoid A (1), an unprecedented meroterpenoid possessing a highly functionalized cyclohexadiene moiety (ring C) featuring gem-propane-1,2-dione and methylformate groups, was characterized from mangrove-derived Penicillium simplicissimum MA-332. Due to the highly oxygenated and functionalized ring C and lack of some key correlations, the unambiguous assignment of the planar structure and steric configuration was solved by X-ray crystallographic analysis. Compound 1 exhibited inhibitory activity against influenza neuraminidase in nanomolar quantities.