Traditional Chinese medicine for ischaemic stroke.
Traditional Chinese medicine for ischaemic stroke.
复制标题
DOI：
10.1016/s1474-4422(18)30290-4
复制
发表时间：
2018-09-01
期刊：
影响因子：
--
通讯作者：
Wen, Aidong
中科院分区：
文献类型：
--
作者：
Liu, Tianlong;Ding, Yi;Wen, Aidong
尽管取得了进展，但缺血性卒中的预防和治疗仍然是全球面临的挑战。一个核心问题是与抗凝剂和抗血小板药物相关的出血风险。中医药因其副作用少，常被用作缺血性脑卒中预防和康复干预的替代药物。中医是指最古老的治疗方法之一，主要包括自然药物，针灸和物理疗法。天然药物是一种尚未开发的生物资源，是许多新药的来源。2例如，丹参在中国用于治疗脑血管疾病已有数千年的历史。一项有106名参与者的对照试验表明，丹参滴丸（一种专利的经典中药）治疗显著降低了中风或短暂性脑缺血发作复发的风险。3中医药在人类的实践已经有2000多年的历史，这些宝贵的实践经验可以为药物发现提供强有力的线索。4中药在中国和其他亚洲国家广泛使用，这些国家的缺血性中风负担很高，因此为开发治疗这种疾病的新的中药衍生药物提供了许多机会。但中医药研究仍存在一定的局限性，如中医药临床试验质量不高等。虽然中医理论对非中国医生来说可能是晦涩难懂的，但中医的价值不应被研究人员忽视。现在需要开展国际合作和对话，以挖掘中药衍生药物的潜力，为缺血性中风患者带来益处。
Despite progress, the prevention and treatment of ischaemic stroke remains a challenge worldwide. A core problem is the risk of haemorrhage associated with anticoagulants and antiplatelet drugs. Because of fewer side-effects, traditional Chinese medicine (TCM) is often sought to provide alternative pharmacotherapy for prevention and rehabilitation intervention of ischaemic stroke in China. TCM refers to one of the oldest healing practices, mainly including natural medication, acupuncture, and physiotherapy. 1 Natural medicine—an untapped biological resource—is the origin of many new drugs. 2 For example, Danshen (Salvia miltiorrhiza) has been used to treat cerebrovascular diseases for thousands of years in China. A controlled pilot trial with 106 participants showed that treatment with a Danshen dripping pill (a patented classic Chinese medicine) significantly reduced the risk for recurrence of stroke or transient ischaemic attack. 3TCM has been practised in human beings for more than 2000 years; the precious experience afforded by this practice can offer powerful leads for drug discovery. 4 TCM is widely used in China and other Asian countries where the burden of ischaemic stroke is high, thereby presenting many opportunities for the exploration of new TCM-derived drugs for this disease. However, there are still some limitations of TCM, such as the low quality of TCM trials. Although TCM theory might be obscure or difficult to understand for non-Chinese doctors, the value of TCM should not be ignored by researchers. International cooperation and dialogue is now needed to tap into the potential of TCM-derived agents to bring benefits to patients with ischaemic stroke.