Prevalence of Malignancies in Patients With Primary Aldosteronism.
Prevalence of Malignancies in Patients With Primary Aldosteronism.
复制标题
原发性醛固酮增多症患者的恶性肿瘤患病率。
DOI：
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发表时间：
2016
影响因子：
5.8
通讯作者：
S. Hahner
中科院分区：
文献类型：
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作者：
K. Lang;K. Weber;M. Quinkler;A. Dietz;H. Wallaschofski;A. Hannemann;N. Friedrichs;L. Rump;Britta Heinze;C. Fuss;I. Quack;H. Willenberg;M. Reincke;B. Allolio;S. Hahner
上下文
原发性醛固酮增多症（PA）是继发性高血压最常见的原因。醛固酮过量可引起体外和体内DNA损伤。单个病例报告表明PA与肾细胞癌和其他肿瘤的一致性。然而，良性和恶性肿瘤的患病率与PA患者尚未进行研究。
患者与设计
在多中心MEPHISTO研究中，研究了335例确诊PA患者的良性和恶性肿瘤患病率。来自波美拉尼亚人群健康研究队列的匹配高血压受试者作为对照。
结果
在335例PA患者中，119例（35.5%）在任何时间被诊断患有肿瘤，30例患有两种或两种以上肿瘤。PA患者中有9.6%报告终生恶性肿瘤发生，而高血压对照组为6.0%（P = 0.08）。有恶性肿瘤病史的PA患者在诊断PA时基线醛固酮水平较高（P = .009），观察到醛固酮水平与恶性肿瘤患病率之间存在强相关性（P = .03）。在PA患者中共发现157个肿瘤，其中61%为良性，25%为恶性（14%的肿瘤性质不明）。肾细胞癌被诊断为五名患者（13%的所有恶性肿瘤），并没有报告在控制
结论
与高血压对照组相比，恶性肿瘤的患病率与醛固酮水平呈正相关，PA患者的醛固酮水平往往更高，但无显著差异。
CONTEXT
Primary aldosteronism (PA) is the most common cause of secondary hypertension. Aldosterone excess can cause DNA damage in vitro and in vivo. Single case reports have indicated a coincidence of PA with renal cell carcinoma and other tumors. However, the prevalence of benign and malignant neoplasms in patients with PA has not yet been studied.
PATIENTS AND DESIGN
In the multicenter MEPHISTO study, the prevalence of benign and malignant tumors was investigated in 335 patients with confirmed PA. Matched hypertensive subjects from the population-based Study of Health in Pomerania cohort served as controls.
RESULTS
Of the 335 PA patients, 119 (35.5%) had been diagnosed with a tumor at any time, and 30 had two or more neoplasms. Lifetime malignancy occurrence was reported in 9.6% of PA patients compared to 6.0% of hypertensive controls (P = .08). PA patients with a history of malignancy had higher baseline aldosterone levels at diagnosis of PA (P = .009), and a strong association between aldosterone levels and the prevalence of malignancies was observed (P = .03). In total, 157 neoplasms were identified in the PA patients; they were benign in 61% and malignant in 25% of the cases (14% of unknown dignity). Renal cell carcinoma was diagnosed in five patients (13% of all malignancies) and was not reported in controls
CONCLUSION
Compared to hypertensive controls, the prevalence of malignancies was positively correlated with aldosterone levels, tended to be higher in PA patients, but did not differ significantly.