Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria.
Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria.
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阿莫地喹-环丙沙星：对抗耐药性疟疾的潜在联合疗法。
DOI：
10.1017/s0031182015000062
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发表时间：
2015
期刊：
影响因子：
2.4
通讯作者：
Gbotosho,GO
中科院分区：
文献类型：
--
作者：
Falajiki,YF;Akinola,O;Abiodun,OO;Happi,CT;Sowunmi,A;Gbotosho,GO
对青蒿素产生抗药性的疟原虫的出现，使得有必要开发新的抗疟疗法。环丙沙星（CFX）是第二代喹诺酮类抗生素，具有一定的抗疟活性。我们研究了CFX与阿莫地喹联合在感染氯喹耐药伯氏疟原虫ANKA的小鼠中的体内抗疟活性。动物经口给予80或160 mg kg−1体重的CFX，每日两次单独给药，或与10 mg kg−1体重的阿莫地喹（AQ）联合给药。在21天内评估动物的寄生虫学活性和存活率。未处理对照组的峰值寄生虫血症为72.51%。AQ单独给药可在第4天清除寄生虫血症，而CFX 80和160 mg kg−1单独给药可分别抑制寄生虫血症13.94 - 54.64%和35.6 - 92.7%。然而，CFX与AQ的组合显著增强了动物对治疗的感染反应（P <0.05），导致CFX 160 mg kg−1的整个随访期间寄生虫血症完全消退，CFX 80 mg kg−1的复发时间延迟，并且动物的存活率显著增加。结果表明，AQ和CFX之间的有益的相互作用，这可能提供一个临床相关的抗疟/抗生素治疗疟疾的管理选择。
Emergence of malaria parasites resistant to artemisinin necessitates the need for development of new antimalarial therapies. Ciprofloxacin (CFX) a second generation quinolone antibiotic possesses some antimalarial activities. We investigated the in vivo antimalarial activities of CFX in combination with amodiaquine in mice infected with chloroquine-resistant Plasmodium berghei ANKA. Animals were treated orally with 80 or 160 mg kg−1 body weight of CFX alone given twice daily or in combination with amodiaquine (AQ) 10 mg kg−1 body weight. Parasitological activity and survival of the animals were assessed over 21 days. Peak parasitaemia in the untreated control group was 72·51%. Treatment with AQ alone resulted in clearance of parasitaemia by day 4 while treatment with CFX 80 and 160 mg kg−1 alone suppressed parasitaemia by 13·94–54·64% and 35·6–92·7%, respectively. However, the combination of CFX with AQ significantly enhanced response of infection in the animals to treatment (P < 0·05) resulting in complete resolution of parasitaemia throughout follow up period with CFX 160 mg kg−1, delayed recrudescence time with CFX 80 mg kg−1 and significant increase in survival rate of the animals. The results demonstrate beneficial interaction between AQ and CFX which may provide a clinically relevant antimalarial/antibiotic therapeutic option in the management of malaria.