Blockade of Basic Fibroblast Growth Factor Retards Recovery from Motor Cortex Injury in Rats
Blockade of Basic Fibroblast Growth Factor Retards Recovery from Motor Cortex Injury in Rats
复制标题
阻断碱性成纤维细胞生长因子可延缓大鼠运动皮层损伤的恢复
DOI：
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发表时间：
1997
影响因子：
3.4
通讯作者：
B. Kolb
中科院分区：
文献类型：
--
作者：
Sharon Rowntree;B. Kolb
单侧运动皮质吸引性损伤后，碱性成纤维细胞生长因子的内源性表达被中和抗体阻断。运动皮质损毁后对照组(生理盐水、山羊免疫球蛋白)大鼠前肢操纵能力恢复缓慢。碱性成纤维细胞生长因子表达受阻的大鼠几乎没有恢复。在解剖学上，对照组损伤大鼠的bFGF和胶质纤维酸性蛋白(GFAP)反应性急剧增加，在剩余运动皮质的V层锥体细胞中，它们的树突分支和棘突密度长期正常。相反，接受bFGF抗体处理的大鼠仅有少量的bFGF反应，正常的GFAP反应，树突枝萎缩，V层锥体细胞内的棘细胞密度降低。这些结果表明，内源性碱性成纤维细胞生长因子的释放在皮质损伤后功能恢复过程中的重要性。
The endogenous expression of basic fibroblast growth factor (bFGF) was blocked by neutralizing antibodies following unilateral suction lesions of the motor cortex. Rats with control treatment (saline, goat IgG) after motor cortex lesions showed slow recovery of forelimb manipulatory abilities. Rats with blockade of bFGF expression showed little recovery. Anatomically, the control‐treated lesioned rats showed an acute increase in bFGF and glial fibrillary acidic protein (GFAP) reactivity, and chronically they had normal dendritic arborization and spine density in layer V pyramidal cells in the remaining motor cortex. In contrast, rats treated with antibodies to bFGF showed little bFGF reactivity, normal GFAP reactivity, and atrophy of dendritic arbor and decreased spine density in layer V pyramidal cells. These results demonstrate the importance of endogenous bFGF release in processes related to functional recovery after cortical injury.
惊厥性癫痫发作后特定大脑区域的碱性成纤维细胞生长因子 mRNA 增加。
DOI：
10.1016/0169-328x(92)90123-s
发表时间：
1992
期刊：
Brain research. Molecular brain research
影响因子：
--
作者：
Riva,MA;Gale,K;Mocchetti,I
通讯作者：
Mocchetti,I