Involvement of p53-dependent apoptosis in radiation teratogenesis and in the radioadaptive response in the late organogenesis of mice.
Involvement of p53-dependent apoptosis in radiation teratogenesis and in the radioadaptive response in the late organogenesis of mice.
复制标题
p53 依赖性细胞凋亡参与辐射致畸和小鼠晚期器官发生的放射适应性反应。
DOI：
10.1269/jrr.42.1
复制
发表时间：
2001
影响因子：
2
通讯作者：
B. Wang
中科院分区：
文献类型：
--
作者：
B. Wang
The irradiation of fetuses at the late period of organogenesis has been known to induce a dramatic increase in malformations. The mechanisms involved, however, have remained unclear for a long time. Using the mouse limb bud system, we first found that radiation-induced apoptosis is involved in the malformation, namely, radiation-induced apoptosis in the predigital regions of embryonic limb buds is responsible for digital defects in mice. An examination of embryonic C57BL/6J mice with different p53 (trp53) status enabled us to further find that susceptibility to radiation-induced apoptosis in the predigital regions and digital defects depend on both the p53 status and the radiation dose; p53 wild-type mice appeared to be the most sensitive, while p53 knockout mice were the most resistant. These results indicate that p53-dependent apoptosis mediates radiation-induced digital defects in the later organogenesis period. The existence of a radioadaptive response in embryonic mice, which has not been reported so far, was found by irradiating embryos with either 5 cGy or 30 cGy on embryonic day 11 prior to a challenging irradiation at 3 Gy on embryonic day 12. p53-heterozygous embryos did not show the radioadaptive response, indicating the involvement of p53 in the radioadaptive response in embryogenesis.
影响因子：
11.2
作者：
Christoph H. Westphal;Katherine P Hoyes;C. Canman;Xin Huang;Michael B. Kastan;J. H. Hendry;Philip Leder
通讯作者：
Christoph H. Westphal;Katherine P Hoyes;C. Canman;Xin Huang;Michael B. Kastan;J. H. Hendry;Philip Leder
细胞凋亡与癌症治疗的关系。
DOI：
--
发表时间：
1994
期刊：
In vivo (Athens, Greece)
影响因子：
--
作者：
Milas,L;Stephens,LC;Meyn,RE
通讯作者：
Meyn,RE